Biology and Bioengineering
YIN Heng
Title: Professor
Subject: Biochemical Engineering
Phone: 0411-84379061
Email: yinheng@dicp.ac.cn
Website:
Research Interests
Glyco-engineering, glycobiology, enzyme-engineering, plant immunity, oligosaccharides
My research interests are in glycoengineering, enzyme-engineering, glycobiology and plant immunity. My research focuses on the utilization of polysaccharide biomass resources in nature, which mainly includes two aspects: the mining and creation of polysaccharide degradation enzymes and efficient degradation of polysaccharides; the functions and mechanisms of oligosaccharides especially the regulation of plant immunity by oligosaccharides.
I have discovered and modified a series of efficient polysaccharide degradation-related enzymes to achieve the preparation of functional oligosaccharides. The effects and mechanisms of polysaccharides and oligosaccharides on the immunity of plants and animals have been systematically studied. I have published more than 100 research papers in Appl Catal B, ACS Catal, J Phys Chem Lett, Bioresource Technol, Carbohyd Polym, Food Chem, AEM, JAFC, MPMI and other journals, 3 books and several book chapters. I have been granted more than 40 patents and have transformed more than 10 into corporate industrial applications. I have developed more than 20 kinds of oligosaccharide-based functional foods, biopesticides and biofertilizers, which have been widely used in China and abroad.
Biography
Group leader, Professor, Natural Products & Glycoengineering Research Group, Dalian Institute of Chemical Physics, CAS, 2015/05 - present
Group leader, Associate Professor, Natural Products & Glycoengineering Research Group, Dalian Institute of Chemical Physics, CAS, 2013/05 - 2015/05
Associate Professor, Natural Products & Glycoengineering Research Group, Dalian Institute of Chemical Physics, CAS, 2011/09 - 2013/04
Assistant Professor, Natural Products & Glycoengineering Research Group, Dalian Institute of Chemical Physics, CAS, 2008/08 - 2011/09
Postdoctoral visiting scientist, Department of Food Science, Faculty of Agricultural Sciences, University of Aarhus, 2010/03 - 2011/02
Ph.D in Biochemical Engineering, Dalian Institute of Chemical Physics, CAS, 2003/09 - 2008/08
Graduate School of the CAS, 2003/09 - 2004/08
Gene Research Center, Medical College of Fudan University, 2004/09 - 2006/07
Dalian Institute of Chemical Physics, CAS, 2006/08 - 2008/08
B.S. in Fine Chemistry; Dalian University of Technology, 1999/09 - 2003/06
Honors and Awards
"Zhang Dayu" Excellent Prof. of DICP, 2019
Outstanding Member of the Youth Association of the Chinese Academy of Sciences, 2019
Liaoning Revitalization Talents, 2018
Distinguished Young Scientists of Dalian city, 2015
Zhang Shuzheng Glycoscience Award for Outstanding Youth, 2015
The second-class award of Liaoning provincial prize for progress in science and technology, 2014
Youth Star science and technology researcher of Dalian city, 2014
The first-class award of Marine Science and Technology Award of China, 2013
YSP Award of Asian Community of Glycoscience and Glycotechnology, 2013
Denmark DANIDA Fellowship, 2010
Publications
1. Tang Li, Ningning Zhang, Shenggang Yan, Shan Jiang, Heng Yin. A Novel Tyrosinase from Armillariaostoyae with Comparable Monophenolase and Diphenolase Activities Suffers Substrate Inhibition. Applied and Environmental Microbiology. 2021, 87(12): 1-14.
2. Xiao Yin, HongguoXie, Ruixin Li, Shenggang Yan, Heng Yin. Regulating association strength between quaternary ammonium chitosan and sodium alginate via hydration. Carbohydrate Polymers.2021,255(117390): 1-8.
3. Guojun Yang, Shuguang Li, Haidong Tan, Kuikui Li, Wei Chen, Heng Yin. A Highly Efficient Biocatalytic Conversion of Renewable Pectic Polysaccharide Biomass into Bioactive Oligogalacturonides. ACS Food Science & Technology.2021, 1(3): 338-346.
4. Hefeng Zhang, Yong Zhao, Huiyan Zhang, Haichuan Zhou, Hong Wang, Xu Zong, Heng Yin, Can Li. Establishing inorganic-biological hybrid photoelectrochemical platform towards sustainable conversion of α-chitin. Applied Catalysis B: Environmental.2020, 265: 118558.
5. Guojun Yang, Haidong Tan, Shuguang Li, Meng Zhang, Jia Che, Kuikui Li, Wei Chen, Heng Yin. Application of engineered yeast strain fermentation for oligogalacturonides production from pectin-rich waste biomas. Bioresource Technology. 2020, 300: 122645.
6. Xiaochen Jia, Haihong Zeng, Santosh Kumar Bose, Wenxia Wang, Heng Yin. Chitosan oligosaccharide induces resistance to Pst DC3000 in Arabidopsis via a non-canonical N-glycosylation regulation pattern. Carbohydrate Polymers.2020, 250: 116939.
7. Haichuan Zhou, Yuebin Zhang, Tang Li, Haidong Tan, Guohui Li, Heng Yin. Distinct Interaction of Lytic Polysaccharide Monooxygenase with Cellulose Revealed by Computational and Biochemical Studies. Journal of Physical Chemistry Letters. 2020,11: 3987-3992.
8. Jia Liu, John F. Kennedy, Xiaofang Zhang, Heng Yin, Wei Chen, Zhuo Chen, Xian Wu, Xuehong Wu. Preparation of alginate oligosaccharide and its effects on decay control and quality maintenance of harvested kiwifruit. Carbohydrate Polymers.2020,242: 116462
9. Santosh Kumar Bose, Prianka Howlader, Wenxia Wang, Heng Yin. Oligosaccharide is a promising natural preservative for improving postharvest preservation of fruit: A review. Food Chemistry.2020, 341: 128178
10. Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. International Journal of Biological Macromolecules. 2020, 152: 180-188.
11. Junjie Liu, Chunguang Zhang, Xiaochen Jia , Wenxia Wang, Heng Yin. Comparative analysis of RNA-binding proteomes under Arabidopsis thaliana-Pst DC3000-PAMP interaction by orthogonal organic phase separation. International Journal of Biological Macromolecules. 2020, 160: 47-54.
12. Prianka Howlader, Santosh Kumar Bose, Xiaochen Jia, Chunlai Zhang, Wenxia Wang, Heng Yin. Oligogalacturonides induce resistance in Arabidopsis thaliana by triggering salicylic acid and jasmonic acid pathways against Pst DC3000. International Journal of Biological Macromolecules. 2020, 164: 4054-4064.
13. Ming Sun, Chu Sun, Tang Li , Kuikui Li, Shenggang Yan, Heng Yin. Characterization of a novel bifunctional mannuronan C-5 epimerase and alginate lyase from Pseudomonas mendocina. sp. DICP-70. International Journal of Biological Macromolecules. 2020, 150: 662–670.
14. Junyan Ma, Tang Li, Haidong Tan, Wujun Liu, Heng Yin. The Important Roles Played in Substrate Binding of Aromatic Amino Acids in Exo-Inulinase From Kluyveromyces cicerisporus CBS 4857. Frontiers in Molecular Biosciences.2020, 7: 569797.
15. Fu Hu, Benwei Zhu, Qian Li, Heng Yin, Yun Sun, Zhong Yao, Dengming Ming. Elucidation of a Unique Pattern and the Role of Carbohydrate Binding Module of an Alginate Lyase. Marine Drugs.2020, 18, 32.
16. Xiaochen Jia, Hongqiang Qin, Santosh Kumar Bose, Tongmei Liu, Jinxia He, Shangqiang Xie, Mingliang Ye, Heng Yin. Proteomics analysis reveals the defense priming effect of chitosan oligosaccharides in Arabidopsis-Pst DC3000 interaction. Plant Physiology and Biochemistry.2020, 149: 301–312.
17. Kuikui Li, Huan Qi, Qishun Liu, Tang Li, Wei Chen, Shuguang Li, Hai-long Piao, Heng Yin. Preparation and antitumor activity of selenium-modified glucomannan oligosaccharides. Journal of Functional Foods.2020, 65: 103731.
18. Shuli Wu, Qishun Liu, Haidong Tan, Fuyun Zhang, Heng Yin. A Novel 2,5-Furandicarboxylic Acid Biosynthesis Route from Biomass-Derived 5-Hydroxymethylfurfural Based on the Consecutive Enzyme Reactions. Applied Biochemistry and Biotechnology.2020, 03290.
19. Xiaochen Jia, Mijanur Rahman Rajib, Heng Yin. Recognition pattern, functional mechanism and application of chitin and chitosan oligosaccharides in sustainable agriculture. Current Pharmaceutical Design.2020, 26: 1-14.
20. Santosh Kumar Bose, Yanqiu He, Prianka Howlader, Wenxia Wang, Heng Yin. The N-glycan processing enzymes beta-D-N-acetylhexosaminidase are involved in ripening-associated softening in strawberry fruit. Journal of Food Science and Technology.2020, 04576.
21. Chunguang Zhang, Wenxia Wang, Xiaoming Zhao, Hongying Wang, Heng Yin. Preparation of alginate oligosaccharides and their biological activities in plants: A review. Carbohydrate Research.2020, 494: 108056.
22. Haidong Tan, Heng Yin. Optimization and characterization of oligosaccharides production from citrus peel waste resource using Aspergillus niger 1805. Journal of Microbiological Methods.2020, 169: 105809.
23. Haidong Tan, Guojun Yang, Wei Chen, Qishun Liu,？Kuikui Li, Heng Yin. Identification and characterization of thermostable endo-polygalacturonase II B from Aspergillus luchuensis. Jouranal of Food Biochemistry. 2020, 13133.
24. Prianka Howlader, Santosh Kumar Bose, Chunguang Zhang, Xiaochen Jia, Wenxia Wang, Heng Yin. Pectin oligosaccharide (POS) induce resistance in Arabidopsis thaliana through salicylic acid-mediated signaling pathway against Pseudomonas syringae pv.tomato DC3000. Physiological and Molecular Plant Pathology.2020, 110: 101483.
2. Xiao Yin, HongguoXie, Ruixin Li, Shenggang Yan, Heng Yin. Regulating association strength between quaternary ammonium chitosan and sodium alginate via hydration. Carbohydrate Polymers.2021,255(117390): 1-8.
3. Guojun Yang, Shuguang Li, Haidong Tan, Kuikui Li, Wei Chen, Heng Yin. A Highly Efficient Biocatalytic Conversion of Renewable Pectic Polysaccharide Biomass into Bioactive Oligogalacturonides. ACS Food Science & Technology.2021, 1(3): 338-346.
4. Hefeng Zhang, Yong Zhao, Huiyan Zhang, Haichuan Zhou, Hong Wang, Xu Zong, Heng Yin, Can Li. Establishing inorganic-biological hybrid photoelectrochemical platform towards sustainable conversion of α-chitin. Applied Catalysis B: Environmental.2020, 265: 118558.
5. Guojun Yang, Haidong Tan, Shuguang Li, Meng Zhang, Jia Che, Kuikui Li, Wei Chen, Heng Yin. Application of engineered yeast strain fermentation for oligogalacturonides production from pectin-rich waste biomas. Bioresource Technology. 2020, 300: 122645.
6. Xiaochen Jia, Haihong Zeng, Santosh Kumar Bose, Wenxia Wang, Heng Yin. Chitosan oligosaccharide induces resistance to Pst DC3000 in Arabidopsis via a non-canonical N-glycosylation regulation pattern. Carbohydrate Polymers.2020, 250: 116939.
7. Haichuan Zhou, Yuebin Zhang, Tang Li, Haidong Tan, Guohui Li, Heng Yin. Distinct Interaction of Lytic Polysaccharide Monooxygenase with Cellulose Revealed by Computational and Biochemical Studies. Journal of Physical Chemistry Letters. 2020,11: 3987-3992.
8. Jia Liu, John F. Kennedy, Xiaofang Zhang, Heng Yin, Wei Chen, Zhuo Chen, Xian Wu, Xuehong Wu. Preparation of alginate oligosaccharide and its effects on decay control and quality maintenance of harvested kiwifruit. Carbohydrate Polymers.2020,242: 116462
9. Santosh Kumar Bose, Prianka Howlader, Wenxia Wang, Heng Yin. Oligosaccharide is a promising natural preservative for improving postharvest preservation of fruit: A review. Food Chemistry.2020, 341: 128178
10. Guojun Yang, Wei Chen, Haidong Tan, Kuikui Li, Junyan Li, Heng Yin. Biochemical characterization and evolutionary analysis of a novel pectate lyase from Aspergillus parasiticus. International Journal of Biological Macromolecules. 2020, 152: 180-188.
11. Junjie Liu, Chunguang Zhang, Xiaochen Jia , Wenxia Wang, Heng Yin. Comparative analysis of RNA-binding proteomes under Arabidopsis thaliana-Pst DC3000-PAMP interaction by orthogonal organic phase separation. International Journal of Biological Macromolecules. 2020, 160: 47-54.
12. Prianka Howlader, Santosh Kumar Bose, Xiaochen Jia, Chunlai Zhang, Wenxia Wang, Heng Yin. Oligogalacturonides induce resistance in Arabidopsis thaliana by triggering salicylic acid and jasmonic acid pathways against Pst DC3000. International Journal of Biological Macromolecules. 2020, 164: 4054-4064.
13. Ming Sun, Chu Sun, Tang Li , Kuikui Li, Shenggang Yan, Heng Yin. Characterization of a novel bifunctional mannuronan C-5 epimerase and alginate lyase from Pseudomonas mendocina. sp. DICP-70. International Journal of Biological Macromolecules. 2020, 150: 662–670.
14. Junyan Ma, Tang Li, Haidong Tan, Wujun Liu, Heng Yin. The Important Roles Played in Substrate Binding of Aromatic Amino Acids in Exo-Inulinase From Kluyveromyces cicerisporus CBS 4857. Frontiers in Molecular Biosciences.2020, 7: 569797.
15. Fu Hu, Benwei Zhu, Qian Li, Heng Yin, Yun Sun, Zhong Yao, Dengming Ming. Elucidation of a Unique Pattern and the Role of Carbohydrate Binding Module of an Alginate Lyase. Marine Drugs.2020, 18, 32.
16. Xiaochen Jia, Hongqiang Qin, Santosh Kumar Bose, Tongmei Liu, Jinxia He, Shangqiang Xie, Mingliang Ye, Heng Yin. Proteomics analysis reveals the defense priming effect of chitosan oligosaccharides in Arabidopsis-Pst DC3000 interaction. Plant Physiology and Biochemistry.2020, 149: 301–312.
17. Kuikui Li, Huan Qi, Qishun Liu, Tang Li, Wei Chen, Shuguang Li, Hai-long Piao, Heng Yin. Preparation and antitumor activity of selenium-modified glucomannan oligosaccharides. Journal of Functional Foods.2020, 65: 103731.
18. Shuli Wu, Qishun Liu, Haidong Tan, Fuyun Zhang, Heng Yin. A Novel 2,5-Furandicarboxylic Acid Biosynthesis Route from Biomass-Derived 5-Hydroxymethylfurfural Based on the Consecutive Enzyme Reactions. Applied Biochemistry and Biotechnology.2020, 03290.
19. Xiaochen Jia, Mijanur Rahman Rajib, Heng Yin. Recognition pattern, functional mechanism and application of chitin and chitosan oligosaccharides in sustainable agriculture. Current Pharmaceutical Design.2020, 26: 1-14.
20. Santosh Kumar Bose, Yanqiu He, Prianka Howlader, Wenxia Wang, Heng Yin. The N-glycan processing enzymes beta-D-N-acetylhexosaminidase are involved in ripening-associated softening in strawberry fruit. Journal of Food Science and Technology.2020, 04576.
21. Chunguang Zhang, Wenxia Wang, Xiaoming Zhao, Hongying Wang, Heng Yin. Preparation of alginate oligosaccharides and their biological activities in plants: A review. Carbohydrate Research.2020, 494: 108056.
22. Haidong Tan, Heng Yin. Optimization and characterization of oligosaccharides production from citrus peel waste resource using Aspergillus niger 1805. Journal of Microbiological Methods.2020, 169: 105809.
23. Haidong Tan, Guojun Yang, Wei Chen, Qishun Liu,？Kuikui Li, Heng Yin. Identification and characterization of thermostable endo-polygalacturonase II B from Aspergillus luchuensis. Jouranal of Food Biochemistry. 2020, 13133.
24. Prianka Howlader, Santosh Kumar Bose, Chunguang Zhang, Xiaochen Jia, Wenxia Wang, Heng Yin. Pectin oligosaccharide (POS) induce resistance in Arabidopsis thaliana through salicylic acid-mediated signaling pathway against Pseudomonas syringae pv.tomato DC3000. Physiological and Molecular Plant Pathology.2020, 110: 101483.