Biology and Bioengineering
LIU Xianming
Title: Associate Professor
Subject: Analytical Chemistry,Biotechnology
Phone:
Email: liuxianming@dicp.ac.cn
Website:
Research Interests
Microfluidics, electrowetting, single-cell study, point of care testing, instrumentation
The past three decades witnessed tremendous scientific and technological advances in microfluidics or lab-on-a-chip. Thanks to the emerging scientific problems and engineering issues raised in biochemistry and biology, which are comprehended in-depth and rapidly addressed, shrinkage in the size of its system promotes the development of novel platforms in the lab-on-chip community. New platforms, featured with the miniaturization of devices and reduced consumption of samples and reagents, bring in numerous benefits, such as reduced costs in chip fabrication, instrumentation, and consumables, faster rates in mass and heat transfers, and greater accuracy in sample manipulation and treatment. Digital microfluidics (DMF) is a multiple-interdisciplinary curriculum and technology in which material science and engineering, electronic engineering, software engineering, mechanical engineering, chemistry, and biology are highly intertwined. How to utilize the means and principles in these related disciplines and thus to integrate a DMF chip, peripheral parts, and subsystems into a comprehensive and fully functionalized chip and system is the key to realizing versatile DMF applications. Therefore, system integration and instrumentation pave the technical foundation for a DMF platform and its applications with high operation efficiency.
The focus of DMF-based instrumentation is shifting from generalized research purpose to specialization in biological, biochemical, clinical and pathogen surveillance applications. It can be envisioned that, as most of the major technical difficulties against the large-scale applications of DMF technology have already been conquered, mass production of affordable DMF chips and expansive engineering implementation of instruments will be coming soon, very likely in an eruptive and subversive way. In the near future, we will witness more industrialized DMF-based instruments developed for specific uses, or they are ringing the doorbells of biologists, biochemists, community health centers, on-field labs in remote or temporary settings, as well as ordinary families. Fig.
Biography
1. Educational experience 1990.9-1995.7
2. Bachelor, Dalian University of Technology 1995.9-1998.7
3. Master, Dalian University of Technology 2000.10-2006.5
4. Doctor of Chemistry, Victoria University of Wellington Working experience 1998.8-2000.9
5. Senior Quality Controller, Pfizer Pharmaceuticals (Dalian) 2005.11-2006.10
6. Research Scientist, Industrial Research Institute, Crown Research Institute, New Zealand 2006.10-2009.8
7. Post-doctoral Fellow, Canterbury University 2010.4-2012.4
8. Post-doctoral Fellow, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 2012.5-2014.7
9. Assistant Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 2014.7- Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Honors and Awards
Publications
1. Huibing Li, # Xianming Liu #*, Fengjiao Zhu, Dachuan Ma, Chunyue Miao, Haoran Su, Jiu Deng, Haiyue Ye, Hongyu Dong, Xue Bai, Yong Luo, Bingcheng Lin, Tingjiao Liu*, Yao Lu*，Spatial barcoding-enabled highly multiplexed immunoassay with digital microfluidics，Biosensors and Bioelectronics 215 (2022) 114557.
2. Y. Xing*, Y. Liu, R. Chen, Y. Li, C. Zhang, Y. Jiang, Y. Lu, B. Lin, P. Chen, R. Tian, Xianming. Liu*, X. Cheng*, A robust and scalable active-matrix driven digital microfluidic platform based on printed-circuit board technology. Lab on a Chip, 2021. 21(10): 1886-1896.
3. Fengjiao Zhu, Yahui Ji, Linmei Li, Xue Bai, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu*. High-throughput single-cell extracellular vesicle secretion analysis on the desktop scanner without cell counting. Analytical chemistry, 2021, 93(39): 13152–13160.
4. Linmei Li, Weiwei Shi, Meimei Liu, Xue Bai, Yanting Sun, Xue Zhu, Haoran Su, Yahui Ji, Fengjiao Zhu, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu*. Single-cell Secretion Analysis in the Engineered Tumor Microenvironment Reveals Differential Modulation of Macrophage Immune Responses. Analytical Chemistry, 2021, 93(9):4198-4207.
5. Zheng T., Z. Gao, Y. Luo*, Xianming. Liu*, W. Zhao and B. Lin (2016). "Manual-slide-engaged paper chip for parallel SERS-immunoassay measurement of clenbuterol from swine hair." Electrophoresis, 2016, 37(3): 418-424.
6. Fan A.，Y. Qu, Xianming Liu, Runtao Zhong,Yong Luo* (2015). “Organ-on-a-Chip: New Platform for Biological Analysis”, Analytical Chemistry Insights,2015, 10, 39-45;
7. Chen X., Y. Luo*, B. Shi*, Z. Gao, Y. Du, Xianming Liu, W. Zhao and B. Lin (2015). "Determination of beta-agonists in swine hair by mu FIA and chemiluminescence." Electrophoresis 36(7-8): 986-993.
8. X. Chen，Y. Luo，B. Shi，Xianming Liu，Z. Gao，Y. Du，W. Zhao，B. Lin，“Chemiluminescence diminishment on a paper-based analytical device: high throughput determination of beta-agonists in swine hair.” Analytical Methods, 2014. 6(24): p. 9684-9690.
9. N. Yang, Xianming Liu*, X. Zhang, B. Lin, H. Yin, Z. Kou, Y. Ding, J. Zhu*, A robust and inexpensive composite insulation layer for digital microfluidic devices. Sensors and Actuators A-Physical, 2014. 219: p. 6-12.2.
10. L. Xiao, Xianming Liu, R. Zhong, K. Zhang, X. Zhang, X. Zhou, B. Lin*, Y. Du*, A rapid, straightforward, and print house compatible mass fabrication method for integrating 3D paper-based microfluidics，Electrophoresis, 2013, 34(20-21), 3003-3007.
11. J. Gao#, X. Liu#, T. Chen, P. Mak, Y. Du, M. Vai, B. Lin* and R. Martins*, An intelligent digital microfluidic system with fuzzy enhanced feedback for multi-droplet manipulation，Lab on a Chip，2013, 13(3), 443-451. （#共同第一作者）
12. X. Liu, K. Baronian and A. Downard*, Direct growth of vertically aligned carbon nanotubes on a planar carbon substrate by thermal chemical vapour deposition，Carbon, 2009, 47 (2), 500-506.
13. X. Liu, K. Baronian and A. Downard*, Patterned Arrays of Vertically Aligned Carbon Nanotube Microelectrodes on Carbon Films Prepared by Thermal Chemical Vapor Deposition，Analytical Chemistry, 2008, 80 (22), 835-8839.
14. X. Liu, J. Spencer, A. Kaiser and M. Arnold*, International Journal of Nanotechnology, 2009, 6(3/4), 329-343.
15. A. Bubendorfer, X. Liu and A. V. Ellis*, Smart Materials and Structures, 2007, 16, 367-371.
16. X. Liu, J. L. Spencer, A. B. Kaiser and W. M. Arnold*, Current Applied Physics, 2006, 6 (3), 427-431.
17. Y. Dai, X. Jian, X. Liu, M. Guiver, “Synthesis and characterization of sulfonated poly(phthalazinone ether sulfone ketone) for ultrafiltration and nanofiltration membranes”. Journal of Applied Polymer Science, 2001. 79(9): p. 1685-1692.