Chemistry and Chemical Engineering
HU Chunxiu
Title: Associate Professor
Subject: Analytical Chemistry,Biotechnology
Phone:
Email: hucx@dicp.ac.cn
Website:
Research Interests
Lipidomics, metabolomics, steroidomics
1. Novel analytical technologies in lipidomics/metabolomics and applications in disease biomarker discovery.
1. Novel analytical technologies in lipidomics/metabolomics and applications in disease biomarker discovery.
2. Development of novel technology in high-throughput single-cell metabolomics analysis
3. Development of novel technology in lipid identification of double bond location isomers
Biography
1. Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 2014.7~present
2. Assistant Professor, Dalian Institute of Chemical Physics, CAS, 2011.07~2014.06
3. Ph.D. in Analytical Chemistry, Dalian Institute of Chemical Physics, CAS, 2005.09~2006.04, 2008.06~2009.05 and 2010.12~2011.06
4. Ph.D. in Analytical Biosciences, Division of Analytical Bioscience, Leiden/Amsterdam Center for Drug Research, Leiden University, a Joint PhD student between CAS and the Royal Netherlands Academy of Arts and Sciences, 2006.5~2008.5 & 2009.6~2010.11
5. M.D. in Physical Chemistry, School of Chemical Engineering, Sichuan University, 2002.9~2005.6
Honors and Awards
Development and application of a high-coverage metabolomics method based on liquid chromatography-mass spectrometry, China Association for Instrumental Analysis (CAIA), CAIA grand prize of Science Technology Award (fifth rank), 2021
2012 Eli Lilly Asia Outstanding Graduate Thesis Award Winner
Publications
1. Yi Xin#, Qintao Wang#, Chen Shen#, Chunxiu Hu*, Xianzhe Shi et al. Medium-Chain Triglyceride Production in Nannochloropsis via a Fatty Acid Chain Length Discriminating Mechanism. Plant Physiol. 2022: kiac396.
2. Qiuhui Xuan Q, Chunxiu Hu, Yinan Zhang, Qingqing Wang, Xinjie Zhao et al. Serum lipidomics profiles reveal potential lipid markers for prediabetes and type 2 diabetes in patients from multiple communities. Front Endocrinol (Lausanne). 2022, 13: 966823.
3. Tianrun Xu, Hang Li, Disheng Feng, Peng Dou, Xianzhe Shi, Chunxiu Hu*, Guowang Xu*, Lipid Profiling of 20 Mammalian Cells by Capillary Microsampling Combined with High-Resolution Spectral Stitching Nanoelectrospray Ionization Direct-Infusion Mass Spectrometry. Anal Chem. 2021, 93(29): 10031-10038.
4. Lichao Wang, Wangjie Lv, Xiaoshan Sun, Fujian Zheng, Tian Run Xu, Xinyu Liu, Hang Li, Xin Lu, Xiaojun Peng, Chunxiu Hu*, Guowang Xu*. Strategy for Nontargeted Metabolomic Annotation and Quantitation Using a High-Resolution Spectral-Stitching Nanoelectrospray Direct-Infusion Mass Spectrometry with Data-Independent Acquisition. Anal Chem. 2021, 93(30): 10528-10537.
5. Tianrun Xu#, Chunxiu Hu#, Guowang Xu*. Recent advances in analytical strategies for mass spectrometry-based lipidomics. Anal Chim Acta. 2020, 1137:156-169.
6. Chunxiu Hu#, Miriam Hoene#, Peter Plomgaard#, Jakob S Hansen, Xinjie Zhao, et al. Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism. J Clin Endocrinol Metab. 2020;105(4): 1-14.
7. Chunxiu Hu#, Yang Zhou#, Jie Feng#, Shiyu Zhou, Chuzhong Li, et al. Untargeted Lipidomics Reveals Specific Lipid Abnormalities in Nonfunctioning Human Pituitary Adenomas. J Proteome Res. 2020; 19(1): 455-463.
8. Xiaoshan Sun, Peichun Wu, Chunxia Zhao, Fujian Zheng, Chunxiu Hu*, et al. Protein profiling analysis based on matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry and its application in typing Streptomyces isolates. Talanta. 2020; 208: 120439.
9. Qian Qin, Disheng Feng, Chunxiu Hu, Bohong Wang, Mengmeng Chang et al. Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones. J Chromatogr A. 2020,1614: 460709.
10. Qiuhui Xuan, Fujian Zheng, Di Yu, Yang Ouyang, Xinjie Zhao, Chunxiu Hu*, Guowang Xu*. Rapid lipidomic profiling based on ultra-high performance liquid chromatography-mass spectrometry and its application in diabetic retinopathy. Anal Bioanal Chem. 2020, 412(15): 3585-3594.
11. Lisa Kappler, Miriam Hoene, Chunxiu Hu, Christine von Toerne, Jia Li, et al. Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab. 2019, 317(2): E374-E387.
12. Qiuhui Xuan#, Chunxiu Hu#, Di Yu, Lichao Wang, Yang Zhou, et al. Development of a high coverage pseudotargeted lipidomics method based on ultra-high performance liquid chromatography-mass spectrometry. Anal Chem. 2018, 90(12): 7608-7616.
13. Qiuhui Xuan#, Chunxiu Hu#, Di Yu, Lichao Wang, Yang Zhou, et al. Development of a High Coverage Pseudotargeted Lipidomics Method Based on Ultra-High Performance Liquid Chromatography-Mass Spectrometry. Anal Chem. 2018, 90(12): 7608-7616.
14. Shuxing Liu#, Lichao Wang#, Chunxiu Hu*, Xin Huang, Liu H, et al. Plasma metabolomics profiling of maintenance hemodialysis based on capillary electrophoresis - time of flight mass spectrometry. Sci Rep. 2017, 7(1): 8150.
15. Hongyu Wang*, Chao Quan, Chunxiu Hu, Bingxian Xie, Yinan Du, et al. A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model. Biol Open. 2016, 5(7): 979-86.
16. Jieyu Zhao#, Yanni Zhao#, Chunxiu Hu, Chunxia Zhao, Junjie Zhang, et al. Metabolic Profiling with Gas Chromatography-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry Reveals the Carbon-Nitrogen Status of Tobacco Leaves Across Different Planting Areas. J Proteome Res. 2016, 5(2): 468-476.
17. Lichao Wang, Chunxiu Hu, Shuxin Liu, Ming Chang, Peng Gao, et al. Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography-Mass Spectrometry. J Proteome Res. 2016, 15(6): 1986-1994.
18. Shuangyuan Wang, Lizhen Qiao, Xianzhe Shi*, Chunxiu Hu, Hongwei Kong. On-line stop-flow two-dimensional liquid chromatography-mass spectrometry method for the separation and identification of triterpenoid saponins from ginseng extract. Anal Bioanal Chem. 2015, 407(1): 331-341.
19. Chunxiu Hu, Guowang Xu*. Metabolomics and traditional Chinese medicine. Trend Anal Chem. 2014, 61: 207-214.
20. Yifei Zhang#, Chunxiu Hu#, Jie Hong#, Jun Zeng, Shenghan Lai, et al. Lipid profiling reveals different therapeutic effects of metformin and glipizide in patients with tpe 2 diabetes and coronary artery disease. Diabetes Care. 2014, 37(10), 2804-2812.
21. Chunxiu Hu, Guowang Xu*. Mass-spectrometry-based-metabolomics analysis for foodomics. Trend Anal Chem. 2013, 52: 36-46.
22. Jia Li, Chunxiu Hu, Xinjie Zhao, Weidong Dai, Shili Chen et al. Large-scaled human serum sphingolipid profiling by using reversed-phase liquid chromatography coupled with dynamic multiple reaction monitoring of mass spectrometry: method development and application in hepatocellular carcinoma. J Chromatogr A. 2013, 1320: 103-110.
23. Chunixu Hu#, Heng Wei#, Anita M. van den Hoek, Mei Wang, Rob van der Heijden, et al. Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice. PLoS One. 2011, 6(5): e19423.
24. Chunxiu Hu#, Heng Wei#, Hongwei Kong, Jildau Bouwman, Vanessa Gonzalez-Covarrubias et al. Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats. Mol Biosyst. 2011, 7(11):3094-3103.
25. Chunxiu Hu, Hongwei Kong, Fengxu Qu, Yong Li, Zhenqiu Yu et al. Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy. Mol Biosyst. 2011, 7(12): 3271-3279.
26. Chunxiu Hu#, Miriam Hoene#, Xinjie Zhao, Hans U. H？ring, Erwin Schleicher et al. Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice. PLoS One. 2010, 5(10): e13318.
27. Chunxiu Hu, Rob van der Heijden, Mei Wang, Jan van der Greef, Thomas Hankemeier, et al. Analytical strategies in lipidomics and applications in disease biomarker discovery. J Chromatogr B Analyt Technol Biomed Life Sci. 2009, 877(26): 2836-2846.
28. Chunxiu Hu, Judith van Dommelen, Rob van der Heijden, Gerwin Spijksma, Theo H. Reijmers et al. RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model. J Proteome Res. 2008, 7(11): 4982-4991.