Chemistry and Chemical Engineering
LIU Yu
Title: Professor
Subject: Chemical Biology/Organic Chemistry
Phone:
Email: liuyu@dicp.ac.cn
Website:
Research Interests
Fluorescence sensor, protein aggregation, amyloid, chemical proteomics
 
1. Development of imaging toolbox to resolve protein misfolding and aggregation states during protein phase separation.
2. Development of high throughput methods for early diagnosis and drug screening.
3. Development of chemical probes to dissect drug target engagement.
Biography

Dalian Institute of Chemical Physics, CAS, Professor, 2019/01 - present 

The Pennsylvania State University, Postdoctoral Fellow., 2015/10 - 2018/12 

The Scripps Research Institute, Ph.D, Chemical Biology, 2010/08 - 2015/09 

National University of Singapore, B. Appl. Sci in Applied Chemistry (1st Class Honours), 2006/08 - 2010/06 

Honors and Awards
 
Publications

1. Liu, Y.; Wolstenholme, C. H.; Carter, G. C.; Liu, H.; Hu, H.; Grainger, L. S.; Miao, K; Fares, M;Hoelzel, C. A.; Yennawar, H. P.; Ning, G.; Du, M.; Bai, L.; Li, X.; Zhang, X.*, Modulation of Fluorescent Protein Chromophores to Detect Protein Aggregation with Turn-on Fluorescence. J. Am. Chem. Soc., 2018, 140(24), 7381-7384. 

2. Liu, Y.; Fares, M.; Dunham, N. P.; Gao, Z.; Miao, K.; Jiang, X.; Bollinger, S. S.; Boal, A. K.; Zhang, X.*, AgHalo: A Facile Fluorogenic Sensor to Detect Drug Induced Proteome Stress. Angew Chem Int Ed Engl, 2017, 56, 8672-8676. 

3. Liu, Y.; Zhang, X.; Chen, W.; Tan, Y. L.; Kelly, J. W.*, Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells. J. Am. Chem. Soc., 2015, 137 (35), 11303-11.

4. Liu, Y.; Zhang, X.; Tan, Y. L.; Bhabha, G.; Ekiert, D. C.; Kipnis, Y.; Bjelic, S.; Baker, D.; Kelly, J. W.*, De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters. J. Am. Chem. Soc., 2014, 136 (38), 13102-5.

5. Liu, Y.; Tan, Y. L.; Zhang, X.*; Bhabha, G.; Ekiert, D. C.; Genereux, J. C.; Cho, Y.; Kipnis, Y.; Bjelic, S.; Baker, D.; Kelly, J. W.*, Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proc. Natl. Acad. Sci. U.S.A., 2014, 111 (12), 4449-54.