Chemistry and Chemical Engineering
LIU Zheyi
Title: Associate Professor
Subject: Analytical Chemistry,Biotechnology
Phone:
Email: zy_liu@dicp.ac.cn
Website:
Research Interests
Native mass spectrometry, ultraviolet photodissociation, structural proteomics
1. Build ultraviolet photodissociation-high resolution mass spectrometry platform, develop methods for the characterization of sequences, modifications and structures of biomolecules. 
2. Develop structural proteomic analysis methods for complex biological samples to achieve high-throughput analysis of protein structures and drug small molecule target proteins. 
3. Establish methods for high-efficiency fractionation and chromatographic separation of intact proteins, develop high-efficiency MS dissociation techniques, and realize large-scale analysis of intact protein sequences and modifications.
Biography
1. Associate Professor, Dalian Institute of Chemical Physics, CAS, 2021/07 – 
2. Research Associate, Dalian Institute of Chemical Physics, CAS, 2017/08 – 2021/06 
3. Ph.D. in Analytical Chemistry, Dalian Institute of Chemical Physics, CAS, 2011/09 - 2017/07 
4. B.S. in College of Chemical Engineering and Materials Science, Zhejiang University of Technology, 2007/09 - 2011/06
Honors and Awards
 
Publications
1. Xiong Chen#; Shanping Ji#; Zheyi Liu#; Xiao Yuan; Congsheng Xu; Ruxi Qi; An He; Heng Zhao; Haiping Song; Chunlei Xiao; Weina Gao; Peng R. Chen; Ray Luo; Pengfei Li*; Fangjun Wang*; Xueming Yang; Ruijun Tian*; Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics, Cell Chemical Biology, 2022 
2. Zheyi Liu#; Wenxiang Zhang#; Binwen Sun; Yaolu Ma; Min He; Yuanjiang Pan*; Fangjun Wang*; Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling, Chemical Science, 2021, 12, 1451 
3. Zheyi Liu#; Zhimin Li#; Guanna Li#; Zhipeng Wang; Can Lai; Xiaolei Wang; Evgeny A. Pidko; Chunlei Xiao*; Fanjun Wang*; Gao Li*; Xueming Yang, Single-Atom Pt+ Derived from the Laser Dissociation of a Platinum Cluster: Insights into Nonoxidative Alkane Conversion, The Journal of Physical Chemistry Letters, 2020, 11(15), 5987 
4. Binwen Sun#; Zheyi Liu#; Zheng Fang; Wei Dong; Yang Yu; Mingliang Ye; Lin Liu; Hongda Wang; Fangjun Wang*; Probing the proteomics dark regions by VAILase cleavage at aliphatic amino acids, Analytical Chemistry, 2020, 92(3), 2770 
5. Zheyi Liu; Ye Zhou; Jing Liu; Jin Chen; Albert J. R. Heck; Fangjun Wang*, Reductive methylation labeling, from quantitative to structural proteomics, TrAC Trends in Analytical Chemistry, 2019, 118, 771