Chemistry and Chemical Engineering
CHEN Yang
Title: Associate Professor
Subject: Biotechnology,Analytical Chemistry
Phone:
Email: chenyang2808@dicp.ac.cn
Website:
Research Interests
Cancer biology, molecular biology, drug discovery, structural pharmacology
1. Functional and mechanism study on human cancer related proteins. 
2. Drug discovery of active ingredient from Chinese Medicine. 
3. Pharmacological investigation into potential drugs and targets in human cancers.
Biography
1. Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 2021/01 - present 
2. Postdoctoral Visiting Fellow, National Institutes of Health, USA, 2017/04 - 2020/11 
3. Postdoctoral Fellow, University of Cincinnati College of Medicine, USA, 2018/09 - 2019/09 
4. Ph.D. in Physical Chemistry, Sun Yat-sen University Cancer Center, 2013/08 - 2017/06 
5. M.Med. in Pathology and Pathophysiology, Southeast University, 2010/09 – 2013/06 
6. B.S. in Biological Sciences, Jiangxi University of Chinese Medicine, 2006/09 - 2010/06
Honors and Awards
1. Dalian Youth Science and Technology Star, 2021 
2. Dalian Introduced High-Level Talent, 2021 
3. State-Level Ganjiang New Area High-Level Talent, 2021 
4. Jiangxi “Double Thousand Plan” Innovation Leading Talent, 2020 
5. NIH Visiting Fellow Award (USA), 2017/2019 
6. Best Poster Award in the 5th International Symposium on Membrane Biology, 2016
Publications
1. Gang Chen, Imran Mahmood Khan, Wensen He, Yongxin Li, Peng Jin, Oswaldo H. Campanella, Haihua Zhang, Yanrong Huo, Yang Chen*, Huqing Yang*, Ming Miao*, Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects, Comprehensive Reviews in Food Science and Food Safety, 2022, 21(3), 2688-2714. 
2. Qixin Chen, Minggang Hao, Lei Wang, Linsen Li, Yang Chen, Xintian Shao, Zhiqi Tian, Richard A. Pfuetzner, Qing Zhong, Axel T. Brunger, Jun-Lin Guan, Jiajie Diao, Prefused lysosomes cluster on autophagosome regulated by VAMP8, Cell Death and Disease, 2021 12(10), 939. 
3. Hong Zhang, Shihui Zhang, Jiali Hu, Yutong Wu, Xiaoyan Ma, Yang Chen, Bing Yu, Shuang Liao, Huilin Huang, Song Gao, Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C, Cancer Communications, 2021, 41(7), 615-630. 
4. Jun Yin, Emma Spillman, Ethan S. Cheng, Jacob Short, Yang Chen, Jingce Lei, Mary Gibbs, Justin S. Rosenthal, Chengyu Sheng, Yuki X. Chen, Kelly Veerasammy, Tenzin Choetso, Rinat Abzalimov, Bei Wang, Chun Han, Ye He, Quan Yuan, Brain-specific lipoprotein receptors interact with derived apolipoprotein and mediate neuron-glia lipid shuttling, Nature Communications, 2021, 12(1), 2408. 
5. Jiali Hu, He Liang, Hong Zhang, Mingzhu Yang, Wei Sun, Peng Zhang, Li Luo, Jianxiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jinyu Yang, Qingsong Gao, Yongkang Long, Xiaoyan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Musheng Zeng, Nan Cao, Jichang Wang, Wei Chen, Huangtian Yang, Song Gao, FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells, Nucleic Acids Research, 2020, 48(5), 2733-2748. 
6. Yingnan Wang, Yunxin Lu, Jie Liu, Ying Jin, Huichang Bi, Qi Zhao, Zexian Liu, Yingqin Li, Jiajia Hu, Hui Sheng, Yiming Jiang, Chao Zhang, Feng Tian, Yang Chen, Zhizhong Pan, Gong Chen, Zhaolei Zeng, Kaiyan Liu, Marcia Ogasawara, Jingping Yun, Huaiqiang Ju, Jianxiong Feng, Dan Xie, Song Gao, Weihua Jia, Scott Kopetz, Ruihua Xu, Feng Wang, AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through phosphorylation of glutathione reductase. Oncogene, 2019, 39(3), 637-650. 
7. Qixin Chen, Xintian Shao, Ziqi Tian, Yang Chen, Payel Mondal, Fei Liu, Fengshan Wang, Peixue Ling, Weijiang He, Kai Zhang, Zijian Guo, Jiajie Diao, Nanoscale Monitoring of Mitochondria and Lysosomes Interactions for Drug Screening and Discovery Strategies, Nano Research, 2019, 12(5), 1009-1015. 
8. Tae-Sung Kim, Liang Zhang, JongIl Ah, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, Yun-Xing Wang, Bo Yeon Kim, Jung-Eun Park, Kyung S. Lee, Molecular architecture of a cylindrical self-assembly at human centrosomes, Nature Communications, 2019, 10, 1151. 
9. Jinyu Yang, Xiangyu Den, Yisheng Li, Xiancai Ma, Jianxiong Feng, Bing Yu, Yang Chen, Yiling Luo, Xi Wang, Meiling Chen, Zhixin Fang, Fuxiang Zheng, Yiping Li, Qian Zhong, Tie-Bang Kang, Libing Song, Ruihua Xu, Musheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao, Structure of Schlafen13 reveals a new class of tRNA/rRNA-targeting RNase engaged in translational control, Nature Communications, 2018, 9, 1165. 
10. Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao, Song Gao, Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET, Nature Communications, 2017, 8, 15744. 
11. Yulu Cao, Shuxia Meng, Yang Chen, Jianxiong Feng, Dongdong Gu, Bing Yu, Yujie Li, Jinyu Yang, Shuang Liao, David C. Chan, Song Gao, MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion, Nature, 2017, 542, 372-376. 
12. Jiali Hu, Yijun Hua, Yang Chen, Bing Yu, Song Gao, Structural analysis of tumor-related single amino acid mutations in human MxA protein. Cancer Communications, 2015, 34, 583-593. 
13. Ze He, Tian Tian, Dan Guo, Huijuan Wu, Yang Chen, Yongchen Zhang, Qing Wan, Huzi Zhao, Congyang Wang, Hongjing Shen, Lei Zhao, Xiaodong Bu, Meiling Wan, Chuanlu Shen, Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling, PLOS One, 2014, 9, e94134.