Chemistry and Chemical Engineering
ZHOU Han
Title: Associate Professor
Subject: Analytical Chemistry
Phone:
Email: zhouhan418@dicp.ac.cn
Website:
Research Interests
Structural biology of G-protein coupled receptors, drug discovery from natural products, protein/complex structure prediction, in silico prediction and simulation of drug-target interactions
1. Structural biology and functional detection of pharmaceutical targets, especially G-protein coupled receptors, through high-throughput screening techniques;
1. Structural biology and functional detection of pharmaceutical targets, especially G-protein coupled receptors, through high-throughput screening techniques;
2. Drug discovery from natural products, including bioactivities and functions on target proteins, and ligand-receptor interactions;
3. AI- and physical model-based protein structure prediction and complex prediction by deep-learning workflows;
4. In silico prediction of drug-target binding and interactions, and dynamic calculations of complexes, by approaches of virtual screening, molecular docking and dynamics.
Biography
1. Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 2020/07 - present
2. Visiting Scholar, Irving Cancer Research Center, Columbia University Medical Center, 2019/05-2020/06
3. Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 2018/06 -2019/04
4. Assistant Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 2016/09 -2018/05
5. Postdoctoral Research Fellow, Center for Drug Discovery, Northeastern University, 2014/02-2016/06
6. PhD, Department of Chemistry and Chemical Biology, Northeastern University, 2007/09-2014/01
7. BS, Department of Chemistry, University of Science and Technology of China, 2003/09-2007/07
Honors and Awards
N/A
Publications
1. Yang Xu, Yanfang Liu*, Han Zhou, Rong Wang, Dongping Yu, Zhimou Guo, Xinmiao Liang*, A guide of column selection for two-dimensional liquid chromatography method development of natural alkaloids, Talanta, 2023, 251, 123738
2. Wei Si, Lele Xiong, Han Zhou, Huimin Wu, Zhe Liu, Guoqiang Liu, Yanfang Liu, Aijin Shen*, Xinmiao Liang*, Comprehensive characterization of ingredients in Crocus sativus L. from different origins based on the combination of targeted and nontargeted strategies, Food Chemistry, 2022, 397, 133777
3. Hong-Li Wei, Yao-Peng Zhao, Ji-Xia Wang, Yang Han, Hao Li, Han Zhou, Tao Hou, Chang-Jian Wang, Yu-Min Yao, Xiu-Li Zhang, Yan-Fang Liu*, Xin-Miao Liang*, Menisperdaurines AW, structurally diverse isoquinoline alkaloids from Menispermum dauricum and their dopamine D1 receptor activities, Bioorganic Chemistry, 2022, 127, 106027
4. Wenyi Yu, Cai Fu, Han Zhou, Guoqiang Liu, Jinlei Zheng, Hongjiang Liu, Meng Li, Aijin Shen*, Yanfang Liu*, Xinmiao Liang, Integrated strategy for identifying isoflavones in Belamcandae Rhizoma based on the combination of mass defect filtering and neutral-loss-triggered multistage fragmentation, Journal of Chromatography A, 2022, 1679, 463379
5. Yang Han, Tao Hou, Zi-Hui Zhang, Yun-Hui Zhu, Jun-Xiang Cheng, Han Zhou, Ji-Xia Wang, Jia-Tao Feng, Yan-Fang Liu*, Zhi-Mou Guo*, Xin-Miao Liang, Corybungines A？ K: Isoquinoline alkaloids from Corydalis bungeana with dopamine D2 receptor activity, Phytochemistry, 2022, 199, 113209
6. Chunying Song, Dongping Yu, Gaowa Jin, Yongzheng Zhou, Ziwei Han, Han Zhou, Liduo Huo, Lijie Liu, Zhimou Guo*, Xinmiao Liang*, Synthesis and Chromatographic Evaluation of Perfluorooctyl Stationary Phase for Separation of Basic Compounds, Chromatographia, 2022, 85 (5), 447-454
7. Fangfang Xu, Jun Wang, Pan Wang, Tao Hou, Han Zhou, Yaopeng Zhao, Jixia Wang*, Yanfang Liu*, Xinmiao Liang*, Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling, European Journal of Pharmacology, 2022, 917, 174760
8. Hong-Li Wei, Yang Han, Han Zhou, Tao Hou, Yu-Min Yao, Chun-Mei Wen, Chao-Ran Wang, Ji-Xia Wang, Ai-Jin Shen, Xiu-Li Zhang, Hao Li*, Yan-Fang Liu*, Isoquinoline alkaloid dimers with dopamine D1 receptor activities from Menispermum dauricum DC, Phytochemistry, 2022, 194, 113015
9. Han Zhou, Tao Hou, Zhenhua Gao, Xiujie Guo, Chaoran Wang, Jixia Wang*, Yanfang Liu, Xinmiao Liang, Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays, Journal of Ethnopharmacology, 2021, 278, 114335
10. Cheng Chen, Xiaofei Zhang, Xuefang Dong, Han Zhou, Xiuling Li*, Xinmiao Liang*, TiO2 Simultaneous Enrichment, On-Line Deglycosylation, and Sequential Analysis of Glyco- and Phosphopeptides, Frontiers in Chemistry, 2021, 9: 0-703176.
11. Lai Wei, Tao Hou, Jiaqi Li, Xiuli Zhang, Han Zhou, Zhenyu Wang, Junxiang Cheng, Kaijing Xiang, Jixia Wang, Yaopeng Zhao*, Xinmiao Liang*, Structure–Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle, Journal of Medicinal Chemistry, 2021, 64 (5), 2634-2647
12. Dian Liu, Yang Han, Han Zhou, Hongli Jin, Hongjian Kang, Feifei Huang, Yanfang Liu*, Xinmiao Liang*, Offline preparative three-dimensional HPLC for systematic and efficient purification of alkaloids from Gelsemium elegans Benth., Journal of Chromatography A, 2021, 1640, 461935
13. Han Zhou, Xingrong Peng, Tao Hou, Nan Zhao, Minghua Qiu, Xiuli Zhang*, Xinmiao Liang, Identification of novel phytocannabinoids from Ganoderma by label-free dynamic mass redistribution assay, Journal of ethnopharmacology, 2020, 246, 112218
14. Rong Wang, Yanfang Liu*, Han Zhou, Yue Chen, Jixia Wang, Xiuli Zhang, Ruitao Yu, Xinmiao Liang*, Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery, Journal of Chromatography A, 2020, 1616, 460779
15. Jingyu Yan, Junjie Ding, Gaowa Jin, Zhaojun Duan, Fan Yang, Dandi Li, Han Zhou, Ming Li, Zhimou Guo*, Wengang Chai*, Xinmiao Liang*, Profiling of Human Milk Oligosaccharides for Lewis Epitopes and Secretor Status by Electrostatic Repulsion Hydrophilic Interaction Chromatography Coupled with Negative-Ion Electrospray Tandem Mass Spectrometry, Analytical chemistry, 2019, 91 (13), 8199-8206
16. Yancheng Hu, Lin Yuan, Xiuli Zhang, Han Zhou, Pan Wang, Guangyi Li, Aiqin Wang, Yu Cong, Tao Zhang, Xinmiao Liang, Wei Li*, Ning Li*, Production of 1,2-Cyclohexanedicarboxylates from Diacetone Alcohol and Fumarates, ACS Sustainable Chemistry & Engineering, 2019, 7, 2980-2988
17. Fangfang Xu, Han Zhou, Xiumei Liu, Xiuli Zhang*, Zhiwei Wang, Tao Hou, Jixia Wang, Lala Qu, Pengyu Zhang, Hailong Piao, Xinmiao Liang*, Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products, RSC advances, 2019, 9 (26), 15073-15083
18. Weijia Zhou, Jixia Wang, Yaopeng Zhao, Long Yu, Ye Fang, Hongli Jin, Han Zhou, Pengyu Zhang, Yanfang Liu*, Xiuli Zhang*, Xinmiao Liang*, Discovery of β2-adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography, Journal of Chromatography A, 2018, 1577, 59-65
19. Yingpeng Liu, Lipin Ji, Marsha Eno, Shalley Kudalkar, Ai-Ling Li, Marion Schimpgen, Othman Benchama, Paula Morales, Shu Xu, Dow Hurst, Simiao Wu, Khadijah A Mohammad, JodiAnne T Wood, Nikolai Zvonok, Demetris P Papahatjis, Han Zhou, Chandrashekhar Honrao, Ken Mackie, Patricia Reggio, Andrea G Hohmann, Lawrence J Marnett, Alexandros Makriyannis*, Spyros P Nikas*, (R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes, Journal of medicinal chemistry, 2018, 61 (19), 8639-8657
20. Han Zhou, Yan Peng, Aneetha Halikhedkar, Pusheng Fan, David R Janero, Ganesh A Thakur, Richard W Mercier, Xin Sun, Xiaoyu Ma, Alexandros Makriyannis*, Human cannabinoid receptor 2 ligand-interaction motif: Transmembrane helix 2 cysteine, C2. 59 (89), as determinant of classical cannabinoid agonist activity and binding pose, ACS Chemical Neuroscience, 2017, 8 (6), 1338-1347
21. Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu, Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B Laprairie, Edward L Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A Hanson, Laura M Bohn*, Alexandros Makriyannis*, Raymond C Stevens*, Zhi-Jie Liu*, Crystal structure of the human cannabinoid receptor CB1, Cell, 2016, 167 (3), 750-762. e14
22. Pushkar M Kulkarni, Abhijit R Kulkarni, Anisha Korde, Ritesh B Tichkule, Robert B Laprairie, Eileen M Denovan-Wright, Han Zhou, David R Janero, Nikolai Zvonok, Alexandros Makriyannis, Maria G Cascio, Roger G Pertwee, Ganesh A Thakur*, Novel electrophilic and photoaffinity covalent probes for mapping the cannabinoid 1 receptor allosteric site (s), Journal of medicinal chemistry, 2016, 59 (1), 44-60
23. Go Ogawa, Marcus A Tius*, Han Zhou, Spyros P Nikas, Aneetha Halikhedkar, Srikrishnan Mallipeddi, Alexandros Makriyannis*, 3′-Functionalized adamantyl cannabinoid receptor probes, Journal of medicinal chemistry, 2015, 58 (7), 3104-3116
24. Darryl D Dixon, Marcus A Tius*, Ganesh A Thakur, Han Zhou, Anna L Bowman, Vidyanand G Shukla, Yan Peng, Alexandros Makriyannis*, C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor, Bioorganic & medicinal chemistry letters, 2012, 22 (16), 5322-5325
25. Elvis K Tiburu, Sergiy Tyukhtenko, Han Zhou, David R Janero*, Jochem Struppe, Alexandros Makriyannis*, Human cannabinoid 1 GPCR C-terminal domain interacts with bilayer phospholipids to modulate the structure of its membrane environment, The AAPS journal, 2011, 13 (1), 92-98