Asymmetric synthesis
1. Transition metal-catalyzed asymmetric hydrogenation of heteroaromatic compounds: Asymmetric hydrogenation of heteroaromatic compounds with chiral transition metal complexes as catalysts, especially qunolines, indole, and isoquinolines.
2. Synthesis and application of some novel chiral ligands: Synthesis of some novel chiral ligands with sulfur; Design and synthesis of some new chiral ligands based on Stacking Effects.
3. Asymmetric total synthesis of alkaloids: Total synthesis of some quinoline and isoquinoline alkaloids based on methodology of asymmetric hydrogenation of quinolines and isoquinolines.
Professor, Dalian Institute of Chemical Physics, CAS, 2002 - present
Postdoctor, Pennsylvania State University, 1999 - 2002
Ph.D., Shanghai Institute of Organic Chemistry, CAS, 1993 - 1999
Bachelor, Huaibei Coal Teachers College, 1989 - 1993
Born, 1970
1. Jie Wang, Zhou-Hao Zhu, Mu-Wang Chen, Qing-An Chen and Yong-Gui Zhou.* Catalytic Biomimetic Asymmetric Reduction of Alkenes and Imines Enabled by Chiral and Regenerable NAD(P)H Models. Angew. Chem. Int. Ed. 2019, 58, 1813-1817.
2. Guang-Shou Feng, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of 2-Hydroxypyrimidine/Pyrimidin-2(1H)-one Tautomers. Angew. Chem. Int. Ed. 2018, 57, 5853-5857.
3. Bo Wu, Zhaoyuan Yu, Xiang Gao, Yu Lan* and Yong-Gui Zhou.* Regioselective a-Addition of Deconjugated Butenolides: Enantioselective Synthesis of Dihydrocoumarins. Angew. Chem. Int. Ed. 2017, 56, 4006-4010.
4. Jie Wang, Mu-Wang Chen, Yue Ji, Shu-Bo Hu, and Yong-Gui Zhou.* Kinetic Resolution of Axially Chiral 5- or 8-Substituted Quinolines via Asymmetric Transfer Hydrogenation. J. Am. Chem. Soc. 2016, 138, 10413-10416.
5. Xiang Gao, Bo Wu, Mu-Wang Chen and Yong-Gui Zhou.* Enantioselective Palladium-Catalyzed C-H Functionalization of Indoles Using an Axially Chiral 2,2’-Bipyridine Ligand. Angew. Chem. Int. Ed. 2015, 54, 11956-11960.