Chemistry and Chemical Engineering
JIA Guoqing
Title: Associate Professor
Subject: Catalytic Chemistry
Phone:
Email: gqjia@dicp.ac.cn
Website:
Research Interests
DNA catalysis, Raman spectroscopy
1. DNA catalysis: Non-canonical DNA structures, like G-quadruplexes, have been implicated in variable cellular processes. We focus on the diverse and tunable structures of these non-canonical DNA structures and discuss their potential opportunity in catalysis, with particular attention to the chiral catalysis. It is anticipated that these researches may stimulate new understanding the essential role of non-canonical DNA in the biological process from the perspective of catalysis.
1. DNA catalysis: Non-canonical DNA structures, like G-quadruplexes, have been implicated in variable cellular processes. We focus on the diverse and tunable structures of these non-canonical DNA structures and discuss their potential opportunity in catalysis, with particular attention to the chiral catalysis. It is anticipated that these researches may stimulate new understanding the essential role of non-canonical DNA in the biological process from the perspective of catalysis.
2. Raman spectroscopy: UV (resonance) Raman spectroscopy is employed to probe the structure of biomolecules (protein, DNA and carbohydrate) in aqueous solution. With developing short-wavelength Raman optical activity spectroscopy, we further reveal the chiral feature of biomolecules from the level of vibrational transitions.
Biography
1. Visiting Scholar, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands, 2015/11-2016/10
2. Associate Professor, Dalian Institute of Chemical Physics, CAS, 2012/12-present
3. Assistant Professor, Dalian Institute of Chemical Physics, CAS, 2010/07-2012/12
4. Ph.D. in Physical Chemistry, Dalian Institute of Chemical Physics, CAS, 2002/09-2010/02
5. B.S. in Chemistry and English, Shanxi University, 1998/09-2002/07
Honors and Awards
Publications
1. Zhou, Wenqin; Cheng, Yu; Song, Bo; Hao, Jingya; Miao, Wenhui; Jia, Guoqing*; Li, Can*; Cationic porphyrin-mediated G-Quadruplex DNA oxidative damage: regulated by the initial interplay between DNA and TMPyP4, Biochemistry, 2021, 60(48): 3707-3713
2. Tang, Yuxuan; Cheng, Feng; Feng, Zhaochi; Jia, Guoqing*; Li, Can*; Stereostructural elucidation of glucose phosphorylation by Raman optical activity, J. Phys. Chem. B, 2019, 123(37): 7794-7800
3. Zhang, Ying#; Wang, Peng#; Jia, Guoqing#; Cheng, Feng; Feng, Zhaochi*; Li, Can*; A short-wavelength Raman optical activity spectrometer with laser source at 457nm for the characterization of chiral molecules, Appl. Spectrosc., 2017, 71(9): 2211-2217.
4. Li, Yinhao; Cheng, Mingpan; Hao, Jingya; Wang, Changhao; Jia, Guoqing*; Li, Can*; Terpyridine–Cu(II) targeting human telomeric DNA to produce highly stereospecific G-quadruplex DNA metalloenzyme, Chem. Sci., 2015, 6: 5578-5585.
5. Li, Yinghao#; Jia, Guoqing#; Wang, Changhao; Cheng, Mingpan; Li, Can*; Higher-order human telomeric G-Quadruplex DNA metalloenzymes enhance enantioselectivity in the Diels–Alder reaction, ChemBioChem, 2015, 16: 618-624.