Chemistry and Chemical Engineering
XU Guowang
Title: Professor
Subject: Analytical Chemistry
Phone: 0411-84379530
Email: xugw@dicp.ac.cn
Website:
Research Interests

Metabolomics, exposomics, lipidomics, mass spectrometry, chromatography

 

His main research field is in the chromatography-related research and the metabolomics applications in disease biomarker discovery, traditional Chinese medicines and food safety.

Biography

Director of chromatography Committee of Chinese Chemical Society, 2019/01 - present 

Deputy director of tumor metabolism Committee of China Anti Cancer Association, 2018/08 - present 

Director of CAS Key Laboratory of Separation Science for Analytical Chemistry in Dalian institute of chemical physics, CAS, 2017/01 - present  

Administrative vice-director of Biotechnology Division, DICP, CAS, 2016/04 - present 

Deputy-director of CAS Key Laboratory of Separation Science for Analytical Chemistry in DICP, 2008/12 - 2017/01 

Professor, DICP, CAS, 1997/11 - present 

Universitaet Medizinische Klinik in Tuebingen, Germany, 1995/10 - 1997/09

Assistant Prof. (-1992) and associate Prof. (since 1992) DICP, CAS, 1991/06 - 1997/11

Ph.D. Anal. Chem.DICP, CAS, 1987/09 - 1991/06 

Master degree, Anal. Chem.DICP, CAS, 1984/09 - 1987/09 

Bachelor. Anal. Chem. Zhejiang institute of engineering, 1980/09 - 1984/07 

Honors and Awards

The special prize of Science and Technology of China Association of Instrument Analysis (CAIA), 2020

The second prize of national science and technology progress, 2011

The second prize of Liaoning Province Science and technology invention,2011

Publications

Prof. Xu has co-written 5 books and published more than 490 peer-reviewed papers in the ‘Web of Science Core Collection’ (WoS) indexed journals including PNAS, Nat. Protoc., Nat. Commun., Hepatology, Clin. Chem., Cancer Res., Advanced Science, Diabetes Care, Anal. Chem., TrAC, J. Chromatogr. A, etc. (WoS H-index = 69, Google H-index =87) and holds more than 80 China patents. 

 

Representative publications:

1. Lei You, Fujian Zheng, Chang Su, Limei Wang, Xiang Li, Qianqian Chen, Jing Kou, Xiaolin Wang, Yanfeng Wang, Yuting Wang, Surong Mei, Bing Zhang*, Xinyu Liu*, Guowang Xu* (2022) Metabolome-wide association study of serum exogenous chemical residues in a cohort with 5 major chronic diseases, Environment International, 158, 106919

2. Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8):2519-2537

3. Di Yu#, Yang Liu#, Yiqiang Zhou, Guowang Xu#*, Chunzhang Yang#* (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A. 117(18):9964-9972.

4. Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675 

5. Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich H?ring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810–819

6. Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908"