Mass Spectrometry, rapid detection, online analysis, real-time monitoring, photoionization, chemical ionization, high-resolution time-of-flight mass spectrometry, tandem mass spectrometry, clinical mass spectrometry, industrial process monitoring, environmental detection
1. Development of key components and integrated instruments for high-sensitivity and high-resolution online mass spectrometry, including photoionization source, chemical ionization source, RF-only ion transmission system, and time-of-flight mass analyzer.
2. Tandem mass spectrometry based on ion mobility spectrometry, quadrupole and time-of-flight mass spectrometry, including quadrupole-time-of-flight mass spectrometry (Q-TOF MS), triple quadrupole mass spectrometry (QQQ MS), and ion mobility-mass spectrometry (IM-MS).
3. Applications of online mass spectrometry in clinical diagnosis, industrial process monitoring, and environmental detection.
Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), 2019/07 - Present
Associate Professor, Dalian Institute of Chemical Physics, CAS, 2014/07 - 2019/07
Research Assistant, Dalian Institute of Chemical Physics, CAS, 2012/01 - 2014/07
Ph.D. in Analytical Chemistry, Dalian Institute of Chemical Physics, CAS, 2006/09 - 2012/01
B.S. in Electronic Science and Technology, Sichuan University, 2002/09 - 2006/07
Second Prize of Dalian Patent Award (second author), 2021
Young Scholar of Zhang Dayu by Dalian Institute of Chemical Physics, CAS, 2019
1.Ningbo Wan, Jichun Jiang, Lei Hua*, Haiyang Li*, et al. Sensitive detection of glyoxal by cluster-mediated CH2Br2+ chemical ionization time-of-flight mass spectrometry. Analytica Chimica Acta 2022, 1206, 339612.
2.Ningbo Wan, Jichun Jiang, Lei Hua*, Haiyang Li*, et al. Nonuniform Electric Field-Enhanced In-Source Declustering in HighPressure Photoionization/Photoionization-Induced Chemical Ionization Mass Spectrometry for Operando Catalytic Reaction Monitoring. Analytical Chemistry 2021, 93, 2207.
3.Hanwei Li, Jichun Jiang, Lei Hua*, Di Tian*, et al. Photoionization-induced NO+ chemical ionization time-of-flight mass spectrometry for rapid measurement of aldehydes and benzenes in vehicles. Talanta 2021, 235, 122722.
4.Yuanyuan Xie, Qingyun Li, Lei Hua*, Haiyang Li*, et al. Highly selective and sensitive online measurement of trace exhaled HCN by acetone-assisted negative photoionization time-of-flflight mass spectrometry with in-source CID. Analytica Chimica Acta 2020, 1111, 31.
5.Xuan Chen, Lei Hua*, Jichun Jiang, Haiyang Li*, et al. Multi-capillary column high-pressure photoionization time-of-flight mass spectrometry and its application for online rapid analysis of flavor compounds, Talanta 2019, 201, 33.
6.Yan Wang, Lei Hua*, Qingyun Li, Haiyang Li*, et al. Direct Detection of Small nAlkanes at Sub-ppbv Level by Photoelectron-Induced O2+ Cation Chemical Ionization Mass Spectrometry at kPa Pressure. Analytical Chemistry 2018, 90, 5398.
7.Lei Hua, Keyong Hou, Ping Chen, Haiyang Li*, et al. Realization of In-Source Collision-Induced Dissociation in Single Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Difffferentiation of Isobaric Compounds. Analytical Chemistry 2015, 87, 2427.
8.Lei Hua, Qinghao Wu, Keyong Hou*, Haiyang Li*, et al. Single Photon Ionization and Chemical Ionization Combined Ion Source Based on a Vacuum Ultraviolet Lamp for Orthogonal Acceleration Time-of-Flight Mass Spectrometry. Analytical Chemistry 2011, 83, 5309.
9.Yan Wang, Lei Hua, Haiyang Li*, Youzuo Zhang*, et al. Rapid Identifification of Adulteration in Extra Virgin Olive Oil via Dynamic Headspace Sampling and High-Pressure Photoionization Time-of-Flight Mass Spectrometry. Journal of Agricultural and Food Chemistry 2022, 70, 6775.
10.Jichun Jiang, Lei Hua, Ping Chen*, Haiyang Li*, et al. High Mass Resolution Multireflflection Time-of-Flight Secondary Ion Mass Spectrometer. Journal of the American Society of Mass Spectrometry, 2021, 32, 1196.
11.QingYun Li, Lei Hua, Di Tian*, HaiYang Li*, et al. Single photon ionization time-of-flight mass spectrometry with a windowless RF-discharge lamp for high temporal resolution monitoring of the initial stage of methanol-to-olefifins reaction. Analyst, 2019, 144, 1104.
12.Yan Wang, Lei Hua, Jichun Jiang, Haiyang Li*, et al. High-pressure photon ionization time-of-flight mass spectrometry combined with dynamic purge-injection for rapid analysis of volatile metabolites in urine. Analytica Chimica Acta 2018, 1008, 74.
13.Yan Wang, Jichun Jiang, Lei Hua, Haiyang Li*, et al. High-Pressure Photon Ionization Source for TOFMS and Its Application for Online Breath Analysis. Analytical Chemistry 2016, 88, 9047.
14.Qinghua Zhou, Lei Hua, Changsong Wang, Haiyang Li*, et al. Improved Analytical Performance of Negative 63Ni Ion Mobility Spectrometry for On-line Measurement of Propofol Using Dichloromethane as Dopant. Journal of the American Society of Mass Spectrometry, 2015, 26, 190.
15.Yuanyuan Xie, Lei Hua, Keyong Hou, Haiyang Li*, et al. Long-Term Real-Time Monitoring Catalytic Synthesis of Ammonia in a Microreactor by VUV-Lamp-Based Charge-Transfer Ionization Time-of-Flight Mass Spectrometry. Analytical Chemistry 2014, 86, 7681.
16.Ping Chen, Keyong Hou, Lei Hua, Haiyang Li*, et al. Quasi-Trapping Chemical Ionization Source Based on a Commercial VUV Lamp for Time-of-Flight Mass Spectrometry. Analytical Chemistry 2014, 86, 1332.
17.Qinghao Wu, Lei Hua, Keyong Hou, Haiyang Li*, et al. Vacuum Ultraviolet Lamp Based Magnetic Field Enhanced Photoelectron Ionization and Single Photon Ionization Source for Online Time-of-Flight Mass Spectrometry. Analytical Chemistry 2011, 83, 8992.