Chemistry and Chemical Engineering
CHEN Di
Title: Associate Professor
Subject: Analytical Chemistry
Phone:
Email: di.chen@dicp.ac.cn
Website:
Research Interests
Multi-omics integration, biomolecular interaction prediction
1. Utilizing multi-layer biology networks to perform multi-omics(both bulk sample omics and single cell omics)intergration and develop analysis pipelines, thus to help find potential disease biomarkers or interesting biological mechanisms.
2. Machine learing, data mining and complex network approaches are integrated with bioinformatic methods to mine the biological big-data, and molecular interaction prediction models are developed to predict the complex interactions between different types of molecules.
Biography
1. Associate Professor, Dalian Institute of Chemical Physics, CAS. 2021.07-Now;
2. Research Assistant, Dalian Institute of Chemical and Physics, CAS, 2021.02-2021.06;
3. Postdoctor, Dalian Institute of Chemical and Physics, CAS, 2016.08-2021.01.
Honors and Awards
Dalian Young Star of science and technology，2021
Publications
1. Di Chen, Yiran Zhang, Wen Wang, Huan Chen, et al. Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network. AdvSci(Weinh). 2021, 8, e2100311.
2. Di Chen, Xinjie Zhao,Zhigang Sui,Huan Niu, et al. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. Theranostics. 2020, 10, 2029-2046.
3. Di Chen, Zhen Ning, Huan Chen, Chang Lu, et al. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases. Oncogene. 2020, 39, 587-602.
4. Di Chen, Xiaolong Liu, Tian Xia, Dinesh Tekcham, et al. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network. iScience. 2019, 16, 177-191.