(1) Deciphering the structural basis and mechanistic principles of essential membrane proteins governing fundamental life processes.
(2) Structural Biology-Based Mechanism Elucidation of Bioactive Molecules in Traditional Chinese Medicine (TCM) and novel drug development.
2025/04-present: Dalian Institute of Chemical Physics, CAS, Professor
2021/03-2025/02: National University of Singapore, Research Fellow
2019/02-2021/02: Tianjin Medical University, Post-Doctor
2012/09-2019/01: Shanghai Institute for Biological Sciences, CAS, Ph.D, Biochemistry and Molecular Biology
2008/09-20012/07: Shandong Normal University, B.S., Biotechnology.
[1] Xu, X. #, Shi, H#., Gong, X., Chen, P., Gao, Y., Zhang, X. and Xiang, S., 2020. Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump. eLife,9, p.e53853.
[2.] Xu, X.#, Li, J. #, Chua, W.Z., Pages, M.A., Shi, J., Hermoso, J.A., Bernhardt, T., Sham, L.T. and Luo, M., 2023. Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site. Proceedings of the National Academy of Sciences,120(21), p.e2301897120.
[3] Yu, L. #, Xu, X. #, Chua, W.Z. #, Feng, H. #, Ser, Z., Shao, K., Shi, J., Wang, Y., Li, Z., Sobota, R.M. and Sham, L.T., 2023. Structural basis of peptide secretion for Quorum sensing by ComA. Nature Communications,14(1), p.7178.
[4] Li, J. #, Xu, X. #, Shi, J., Hermoso, J.A., Sham, L.T. and Luo, M., 2023. Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis. Nature Communications, 14(1), p.7999.
[5] Li J.#, Yutong He.#, Xu X.#, Shi J., Hermoso JA., Sham LT., Luo M., 2024 Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division. eLife.