(1) Chinese medicines and drug discovery and development.
(2) Integrative pharmacology、medicinal chemistry、animal models.
(3) Biotechnology R&D.
2024/06-present: Dalian Institute of Chemical Physics, CAS, Professor
2000/10-2024/04: Corning Incorporated, USA, Research Fellow/Technical Lead
1996/10-2000/10: Johns Hopkins University School of Medicine, USA, Postdoctoral
1995/10-1996/10: University of Vermont, USA, Postdoctoral
1992/9-1995/9: Institute of Chemistry, CAS, Ph.D., Physical Chemistry
1989/9-1992/7: Wuhan University, M.S., Physical Chemistry
1985/9-1989/7: Hubei University, BS, Chemistry
[1] Authors Choice Award, SLAS Discovery, 2020 and 2021
[2] “Biophysicist in Profile”, Biophysical Society, 2013
[3] Stookey Award, Corning Incorporated, 2009
[4] Second-Award, 8th National Excellent Books in Science & Technology, China, 1997
[5] President Scholarship Award, Chinese Academy of Sciences, China, 1995
Books
[1] Fang, Y., ed. (2015) Label-Free Biosensor Methods in Drug Discovery. Methods in Pharmacology and Toxicity, Vol. 53, Springer, New York.
[1] Bai, C., Fang, Y., and Tang, Y. (1996) Structure and Biology of Three-Stranded DNA. Chinese Scientific Publishing Co., Beijing, China.
Papers (*Corresponding authors)
[1] Peng, J., Zhao, Y., Hong, Y., Burkhalter, R.S., Hogue, C.L., Tran, E., Wei, L., Romeo, L., Dolley-Sonneville, P., Melkoumian, Z., Liang, X., Fang, Y.* (2018) Chemical identity and mechanism of action and formation of a cell growth inhibitory compound from polycarbonate flasks. Analytical Chemistry 2018, 90(7), 4603–4610.
[2] Fang, Y., Eglen, R.M. (2017) Three-dimensional cell cultures in drug discovery and development. SLAS Discovery 22(5) 456–472.
[3] French, J.B.*, Jones, S.A., Deng, H., Hu, H., Pedley, A.M., Kim, D., Chan, C.Y., Hu, H., Pugh, R.J., Zhao, H., Zhang, Y., Huang, T.J., Fang, Y.,* Zhuang, X.* Benkovic, S.J.* (2016) Spatial colocalization and functional link of purinosomes with mitochondria. Science 351(6274), 733-737.
[4] Fang, Y.* (2012) Ligand-receptor interaction platforms and their applications for drug discovery. Expert Opinion on Drug Discovery 7, 969-988.
[5] Verrier, F., An, S., Ferrie, A.M., Sun, H., Kyoung, M., Fang, Y.*, Benkovic, S.J.* (2011) GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nature Chemical Biology 7, 909-915.
[6] Deng, H., Hu, H., He, M., Hu, J., Niu, W., Ferrie, A.M., Fang, Y.* (2011) Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor-35 (GPR35) agonists. Journal of Medicinal Chemistry 54, 7385-7396.
[7] Ferrie, A. M., Wu, Q., Fang, Y.* (2010) Resonant waveguide grating imager for live cell sensing. Applied Physics Letters 97, 223704.
[8] Fang, Y.* (2006) Spreading and segregation of lipids in air-stable lipid microarrays. Journal of the American Chemical Society 128, 3158-3159.
[9] Fang, Y.*, Ferrie, A.M., Fontaine, N.H., Mauro, J., Balakrishnan, J. (2006) Resonant waveguide grating biosensor for living cell sensing. Biophysical Journal 91, 1925-1940.
[10] Fang, Y., Frutos, A.G., Lahiri, J.* (2002) Membrane protein microarrys. Journal of the American Chemical Society 124, 2394-2395.
[11] Fang, Y. and Hoh, J.H. (1998) Early intermediates in spermidine induced DNA condensation on mica. Journal of the American Chemical Society 106, 8903-8909.