His main research field is in the chromatography-related research and the metabolomics applications in disease biomarker discovery, traditional Chinese medicines and food safety.
He was an editor of J. Chromatgor. B (2007-2014), and is the contributing editor of TrAC, associate editor of Metabolites and members of editorial board of the Anal. Chem. (2021-2022), Anal. Chim. Acta，J. Proteome Res., etc.
He is also a Permanent Scientific Committee (PSC) member of HPLC.
2019/01-present Director of Chromatography Committee of Chinese Chemical Society
2018/08-present Deputy director of Tumor Metabolism Committee of China Anti-Cancer Association
2017/01--present Director of CAS Key Laboratory of Separation Science for Analytical Chemistry in Dalian institute of chemical physics (DICP), CAS
2016/04—2023/11 Administrative vice-director of Biotechnology Division, DICP, CAS
2008/12—2017/01 Deputy-director of CAS Key Laboratory of Separation Science for Analytical Chemistry in DICP
1997/11-present DICP, CAS, Professor
1995/10-1997/09, Universitaet Medizinische Klinik, Tuebingen, Germany
1994/06-2023/11 Principal Investigator (PI) of DICP, CAS
1991/06-1997/11, DICP, CAS, Assistant Prof. (-1992) and associate Prof. (1992-1997.11)
1987/09-1991/06 DICP, CAS, Ph.D. Anal. Chem.
1984/09-1987/09 DICP, CAS, Master ‘ degree, Anal. Chem.
1980/09-1984/07 Zhejiang institute of engineering, bachelor. Anal. Chem.
One achievement was awarded the second prize of national science and technology progress (2011), and the other was awarded the second prize of Liaoning Province Science and technology invention (2011) , the third was awarded the special prize of Science and Technology of China Association of Instrument Analysis (CAIA) (2020).
Model worker of Liaoning Province (2019)
Prof. Xu has co-written 5 books and published more than 550 peer-reviewed papers in the ‘Web of Science Core Collection’ (WoS) indexed journals including PNAS, Nat Protoc, Nat Commun, Hepatology, Cell Metab, Diabetes Care, Cancer Res, Clin Chem, Anal Chem etc. (WoS H-index = 79, Google H-index =99) and holds more than 100 China patents.
Representative publications:
[1] Tianrun Xu, Hang Li, Peng Dou, Yuanyuan Luo, Siming Pu, Hua Mu, Zhihao Zhang, Disheng Feng, Xuesen Hu, Ting Wang, Guang Tan, Chuang Chen, Haiyang Li, Xianzhe Shi*, Chunxiu Hu*, Guowang Xu* (2024) Concentric Hybrid Nanoelectrospray Ionization‐Atmospheric Pressure Chemical Ionization Source for High‐Coverage Mass Spectrometry Analysis of Single‐Cell Metabolomics, Adv Sci, 11: e2306659.
[2] Lei You#, Jing Kou#, Mengdie Wang#, Guoqin Ji#, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu*, Surong Mei*, Guowang Xu* (2024) An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population, Nat Commun,15(1):2268
[3] Yueqiong Ni#, Lingling Qian#, Sara Leal Siliceo#, Xiaoxue Long#, Emmanouil Nychas, Yan Liu, Marsena Jasiel Ismaiah, Howell Leung, Lei Zhang, Qiongmei Gao, Qian Wu, Lina Zhou, Xiaolin Wang, Qi Li, Hani El-Nezami, Aimin Xu, Guowang Xu*, Huating Li*, Gianni Panagiotou*, Weiping Jia* (2023) Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations, Cell Metab., 35, 1530–1547.
[4] Zhen Ning#, Xin Guo#, Xiaolong Liu#, Chang Lu#, Aman Wang, Xiaolin Wang, Wen Wang, Huan Chen, Wangshu Qin, Xinyu Liu, Lina Zhou, Chi Ma, Jian Du, Zhikun Lin, Haifeng Luo, Wuxiyar Otkur, Huan Qi, Di Chen, Tian Xia, Jiwei Liu, Guang Tan*, Guowang Xu*, Hai-long Piao* (2022) USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma, Nat. Commun, 13(1): 2187. doi: 10.1038/s41467-022-29846-9.
[5] Fujian Zheng, Xinjie Zhao, Zhongda Zeng, Lichao Wang, Wangjie Lv, Qingqing Wang, Guowang Xu* (2020) Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, Nature Protocols, 15(8):2519-2537.
[6] Di Yu#, Yang Liu#, Yiqiang Zhou, Guowang Xu#*, Chunzhang Yang#* (2020) Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism, Proc Natl Acad Sci U S A. 117(18):9964-9972.
[7] Zujiang Yu,*, Jingjing Li, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Zhenfeng Duan, Xiaochao Ma, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang*, Guowang Xu*, Quancheng Kan* (2020) Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute-On-Chronic Liver Failure, Advanced Science, 7, 1902996.
[8] Ping Luo#, Peiyuan Yin#, Rui Hua#, Yexiong Tan, Zaifang Li#, Gaokun Qiu, Zhenyu Yin, Xingwang Xie, Xiaomei Wang, Wenbin Chen, Lina Zhou, Xiaolin Wang, Yanli Li, Hongsong Chen, Ling Gao, Xin Lu, Tangchun Wu*, Hongyang Wang*, Junqi Niu*, Guowang Xu* (2018) A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma, Hepatology, 67:662-675
[9] Xinyu Liu, Miriam Hoene, Peiyuan Yin, Louise Fritsche, Peter Plomgaard, Jakob S. Hansen, Christos T. Nakas, Andreas M. Niess, Jens Hudemann, Michael Haap, Maimuna Mendy, Cora Weigert, Xiaolin Wang, Andreas Fritsche, Andreas Peter, Hans-Ulrich Häring, Guowang Xu*, Rainer Lehmann*(2018) Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood, Clin. Chem., 64(5): 810-819
[10] Shuangyuan Wang#, Zhichao Wang#, Lina Zhou, Xianzhe Shi*, Guowang Xu* (2017) Comprehensive analysis of short-, medium- and long-chain acyl-coenzyme As by on-line two dimensional liquid chromatography-mass spectrometry, Anal. Chem., 89(23):12902-12908