(1) New Fluorophore Design and Structure-Fluorescence Relationship.

(2) Protein Labelling and Sensing.

(3) Fluorescent Probes.

(4) Super-Resolution Fluorescent Imaging.

(1) 2022  NSFC Award for Distinguished Young Scholar

(2) 2018  MSMLG Czarnik Emerging Investigator Awards

(4) 2017  Youth Science and Technology Innovation Leader (Ministry of Science and Technology of China)

(5) 2014  NSFC Award for Excellent Young Scholar                                        

(6) 2014  Dalian City Award for Distinguished Young Scholar Cultivation

[1]  Xiangning Fang, Qinglong Qiao*, Zhifeng Li, Hao-Kai Li, Yalin Huang, Dongjie Hou, Jie Chen, Ning Xu, Kai An, Wenchao Jiang, Yi Tao, Pengjun Bao, Yinchan Zhang, Zhimin Wu, Xiaogang Liu*, Zhaochao Xu*, Ether Rhodamines with Enhanced Hydrophilicity, Fluorogenicity, and Brightness for Super-Resolution Imaging, J. Am. Chem. Soc. 2025, 147, 22253–22267.

[2]  Qinglong Qiao, Chao Wang, Hanlixin Wang, Yiyan Ruan, Wenjuan Liu, Jie Chen, Zhimin Wu, Xiaogang Liu* and Zhaochao Xu*, Tail-Assisted Excited-State Intramolecular Proton Transfer (ta-ESIPT) Fluorophores: A Universal Ratiometric Platform for Hydration-Sensitive Biomolecular Imaging and Sensing, J. Am. Chem. Soc. 2025, 147, 15602–15613.

[3]  Qinglong Qiao*, Aoxuan Song, Guanyu Jiang, Yuxin Zhou, Yiyan Ruan, Wenhao Jia, Xiaogang Liu*, Zhaochao Xu*, Whole-cell Lysosome SMLM Imaging as Indicators for Functional Diagnostics with a Low-Phototoxic Spontaneously Blinking Probe, Angew. Chem. Int. Ed., 2025, 64, e202503177.

[4]  Qinglong Qiao#, Aoxuan Song#, Kai An, Ning Xu, Wenhao Jia, Yiyan Ruan, Pengjun Bao, Yi Tao, Yinchan Zhang, Xiang Wang, Zhaochao Xu*, Spontaneously Blinkogenic Probe for Wash-Free Single-Molecule Localization-Based Super-Resolution Imaging in Living Cells, Angew. Chem. Int. Ed., 2025, 64, e202417469.

[5]  Qinglong Qiao, Wenjuan Liu, Yinchan Zhang, Jie Chen, Guangying Wang, Yi Tao, Lu Miao, Wenchao Jiang, Kai An, Zhaochao Xu*, In Situ Real-time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self-assemblies by Super-Resolution Imaging, Angew. Chem. Int. Ed., 2022, 61, e202208678.

[6]  Lu Miao, Wei Zhou, Chunyu Yan, Yuebin Zhang, Qinglong Qiao, Xuelian Zhou, Yingzhu Chen, Guangying Wang, Zhendong Guo, Jun Liu, Hailong Piao, Xia Pan, Mengxue Yan, Weijie Zhao, Guohui Li*, Yueqing Li*, Zhaochao Xu*, Rapid Screening of SARS-CoV-2 Inhibitors via Ratiometric Fluorescence of RBD- ACE2 Complexes in Living Cells by Competitive Binding, Acta. Pharm. Sin. B, 2022, 10.1016/j.apsb.2022.05.033.

[7]  Qinglong Qiao, Wenjuan Liu, Jie Chen, Xia Wu, Fei Deng, Xiangning Fang, Ning Xu, Wei Zhou, Shaowei Wu, Wenting Yin, Xiaogang Liu, Zhaochao Xu*. An Acid-regulated Self-blinking Fluorescent Probe for Resolving Whole-cell Lysosomes with Long-term Nanoscopy. Angew. Chem. Int. Ed., 2022, 61, e202202961.

[8]  Jie Chen, Chao Wang, Wenjuan Liu, Qinglong Qiao, Huan Qi, Wei Zhou, Ning Xu, Jin Li, Hailong Piao, Davin Tan, Xiaogang Liu and Zhaochao Xu*. Stable Super-Resolution Imaging Of Lipid Droplet Dynamics Through A Buffer Strategy With A Hydrogen-Bond Sensitive Fluorogenic Probe. Angew. Chem. Int. Ed., 2021, 60, 25104-25113.

[9]  Weijie Chi, # Qinglong Qiao, # Chao Wang, Jiazhu Zheng, Wei Zhou, Ning Xu, Xia Wu, Xiao Jiang, Davin Tan, Zhaochao Xu* and Xiaogang Liu*. Descriptor ΔG_C-O Enables The Quantitative Design Of Spontaneously Blinking Rhodamines For Live-Cell Super-Resolution Imaging. Angew. Chem. Int. Ed., 2020, 59, 20215-20223.

[10]  Chao Wang#, Qinglong Qiao#, Weijie Chi, Jie Chen, Wenjuan Liu, Davin Tan, Scott McKechnie, Da Lyu, Xiaofang Jiang, Wei Zhou, Ning Xu, Qisheng Zhang, Zhaochao Xu* and Xiaogang Liu*. Quantitative Design of Bright Fluorophores and AIEgens via the Accurate Prediction of Twisted Intramolecular Charge Transfer (TICT). Angew. Chem. Int. Ed., 2020, 59, 10160-10172.

[11]  Weijie Chi#, Jie Chen#, Wenjuan Liu#, Chao Wang, Qingkai Qi, Qinglong Qiao, Tee Meng Tan, Kangming Xiong, Xiao Liu, Keegan Kang, Young-Tae Chang*, Zhaochao Xu*, Xiaogang Liu*. A General Descriptor ΔE Enables the Quantitative Development of Luminescent Materials Based on Photoinduced Electron Transfer. J. Am. Chem. Soc., 2020, 142, 6777-6785.

[12]  Qingkai Qi, Weijie Chi, Yuanyuan Li, Qinglong Qiao,  Jie Chen, Lu Miao, Yi Zhang, Jin Li, Wei Ji, Tao Xu*,  Xiaogang Liu*, Juyoung Yoon*, Zhaochao Xu*. A H-Bond Strategy to Develop Acid-Resistant Photoswitchable Rhodamine Spirolactams for Super-Resolution Single-Molecule Localization Microscopy. Chem. Sci., 2019, 10, 4914-4922.

[13]  Weijie Chi#, Qinglong Qiao#, Richmond Lee, Wenjuan Liu, Yock Siong Teo, Danning Gu, Matthew J. Lang, Young-Tae Chang*, Zhaochao Xu*, Xiaogang Liu*, Photoexcitation Induced Twisted Intramolecular Charge Shuttle (TICS), Angew. Chem. Int. Ed., 2019, 58, 7073-7077

[14]  Xiaogang Liu#*, Qinglong Qiao#, Wenming Tian, Wenjuan Liu, Jie Chen, Matthew J. Lang and Zhaochao Xu*, Aziridinyl Fluorophores Demonstrate Bright Fluorescence and Superior Photostability by Effectively Inhibiting Twisted Intramolecular Charge Transfer, J. Am. Chem. Soc., 2016, 138, 6960- 6963.

[15]  Zhaochao Xu*, Kyung-Hwa Baek, Ha Na Kim, Jingnan Cui, Xuhong Qian, David R. Spring, Injae Shin*, Juyoung Yoon*, Zn²⁺–Triggered Amide Tautomerization Produces a Highly Zn²⁺–Selective, Cell–Permeable and Ratiometric Fluorescent Sensor, J. Am. Chem. Soc., 2010, 132, 601-610.

[16] Zhaochao Xu, N. Jiten Singh, Jeesun Lim, Jie Pan, Ha Na Kim, Sungsu Park, Kwang S. Kim*, Juyoung Yoon*. Unique Sandwich Stacking of Pyrene-Adenine-Pyrenefor Selective and Ratiometric Fluorescent Sensing of ATP at Physiological pH. J. Am. Chem. Soc., 2009, 131, 15528-15533.