People
ZHOU Yongjin
Title: Professor
Subject: Biotechnology
Phone:
Email: zhouyongjin@dicp.ac.cn
Website:
Research Interests

Synthetic biology, metabolic engineering, C1 biotechnology.

 

Engineering microbial (yeast) cell factories for production of chemicals, biofuels and bioactive molecules by developing synthetic biology tools and metabolic engineering principles

Biography
Professor, Dalian Institute of Chemical Physics, CAS, 2018/02 - present 
Associate Professor, Dalian Institute of Chemical Physics, CAS, 2017/01 - 2018/02 
Postdoc, Chalmers University of Technology, Sweden, 2012/06 - 2016/12 
Ph.D. in Biochemical Engineering, Dalian Institute of Chemical Physics, CAS, 2008/09 - 2012/06 
M.S. in Biochemical Engineering, Tianjin University, 2006/09 - 2008/07 
B.S. in Food Science and Technology, Jiangnan University, 2002/09 - 2006/07
Honors and Awards
Zhang Dayu Chair professor, 2021 
The Best Potential Youth Scholar, 2019 
Excellent Young Scholars from NSFC, 2019 
"Lun Shiyi" Distinguished Young Scientists, 2018 
National Talent Program for Young Scientists, 2018 
Young Scholar Award in the Chemical Engineering from NSFC, 2017 
Young Scholar Award of International Metabolic Science Conference, 2016 
The first prize of Chinese Pharmaceutical Association, 2015
Publications

1. Shan Yang, Ruibing Chen, Xuan Cao, Guodong Wang, Yongjin Zhou*, De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast, Nature Communications, 2024, 15, 253.

2. Jiaoqi Gao#, Wei Yu#, Yunxia Li, Mingjie Jin, Lun Yao, Yongjin Zhou*, Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose, Nature Chemical Biology, 2023, 19, 1524-1531.

3. Xiaoxin Zhai, Jiaoqi Gao, Yunxia Li, Martin Grininger, Yongjin Zhou*, Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast, Proceedings of the National Academy of Sciences of the United States of America, 2023, 120(12), e2220816120.

4. Min Ye, Jiaoqi Gao, Yongjin Zhou*, Global metabolic rewiring of the nonconventional yeast Ogataea polymorpha for biosynthesis of the sesquiterpenoid β-elemene, Metabolic Engineering, 2023, 76, 225-231.

5. Jiaoqi Gao, Yunxia Li, Wei Yu, Yongjin Zhou*, Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol, Nature Metabolism, 2022, 4, 932-943.

6. Peng Cai, Xiaoyan Wu, Jun Deng, Yongjin Zhou*, Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris, Proceedings of the National Academy of Sciences of the United States of America, 2022, 119(29), e2201711119.

7. Ruibing Chen, Jiaoqi Gao, Wei Yu, Xianghui Chen, Xiaoxin Zhai, Yu Chen, Lei Zhang*, Yongjin Zhou*, Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast. Nature Chemical Biology, 2022, 18(5), 520-529.

8. Peng Cai#, Xingpeng Duan#, Xiaoyan Wu, Linhui Gao, Min Ye, Yongjin Zhou*, Recombination machinery engineering facilitates metabolic engineering of the industrial yeast Pichia pastoris. Nucleic Acids Research, 2021, 49(13), 7791–7805

9. Tao Yu#, Yongjin Zhou#, Mingtao Huang, Quanli Liu, Rui Pereira, Florian David, Jens Nielsen*, Reprogramming yeast metabolism from alcoholic fermentation to lipogenesis. Cell. 2018, 174(6), 1549-1558.

10. Yongjin Zhou, Eduard Kerkhoven, Jens Nielsen*, Barriers and opportunities in bio-based production of hydrocarbons. Nature Energy, 2018, 3, 925-935.