Speaker：：Qing (Robert) Miao, Ph.D.
Medical College of Wisconsin
Location: Conference Hall, Division of Biotechnology
Dalian Institute of Chemical Physics，CAS
Time: 2016.4.13 (Wednesday) 15:00- 17:00 p.m.
Introduction:
Qing (Robert) Miao, Ph.D.
Associate Professor
Department of Surgery, Divisions of Pediatric Surgery
OFFICE ADDRESS:
Children's Research Institute, C4445
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
Phone: 414-955-5701
Fax: 414-955-6473
E-mail: qmiao@mcw.edu
EDUCATION
09/1986 – 06/1990 BS, Zhejiang University, Hangzhou, China
09/1990 – 06/1995 PhD, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
09/1997 – 06/2002 PhD, Medical University of South Carolina, Charleston, SC
FACULTY APPOINTMENTS:
07/1995 – 06/1996 Assistant Professor, State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
07/2006 – 12/2007 Associate Research Scientist, Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT
12/2007 – 07/2013 Assistant Professor, Department of Surgery (Primary) and Department of Pathology, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, WI
02/2008 – 07/2013 Assistant Professor (adjunct appointment), Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
07/2013 – Present Associate Professor, Department of Surgery (Primary) and Department of Pathology, Children’s Research Institute, Medical College of Wisconsin, Milwaukee, WI
07/2013 – Present Associate Professor (adjunct appointment), Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI
Abstract
Nogo-B receptor (NgBR) was identified as a receptor specific for Nogo-B. Our previous work has shown that Nogo-B and its receptor (NgBR) are essential for chemotaxis and morphogenesis of endothelial cells in vitro and intersomitic vessel formation via Akt pathway in zebrafish. Here, we further demonstrated the roles of NgBR in regulating vasculature development using tissue specific knockout mice. NgBR deficiency results in cerebrovascular malformation and other diseases, such as non-alcohol fatty liver diseases (NAFLD) and breast cancer. Cerebral cavernous malformations (CCMs) are one of major brain vascular malformation. Three genes such as CCM1, CCM2 and CCM3 are involved in the pathogenesis of CCMs. Our studies demonstrated that NgBR regulates the transcription of CCM1 and CCM2. NgBR deficiency is one of risk factors promoting the onset of CCM diseases. In the liver, NgBR deficiency promotes the hepatic lipogenesis and results in the NAFLD. In contrast, NgBR levels increase in the several cancers, such as estrogen receptor positive breast cancer and liver cancer. Our results demonstrated that high expression of NgBR increases the resistance of tumor cells to chemotherapy. In a word, we are using molecular cell biology approach and animal models to elucidate the roles of Nogo-B receptor in the pathogenesis of several diseases.
Contact: Group 1830, Prof. Hai-long Piao（82463004）