Time：10:00 AM, 2/4/2016
Location：Meeting room of Biotechnology Division, Dalian Institute of Chemical Physics
Prof. Renato Zenobi（ETH Zurich）
Research Interests
Analytical chemistry using laser-based mass spectrometric and scanning probe microscopy methods, emphasizing methods development, novel applications, and fundamental/mechanistic aspects. Study of the architecture of large noncovalent complexes by MALDI MS with specialized high-mass detection; MS-based KD determination for protein – ligand systems; conformation of bio-macromolecules in the gas phase; single cell metabolomics; MALDI and ESI mechanisms. Nanoscale chemical analysis using scanning near-field optical methods.
Education
July 1990 Ph.D., Stanford University. Thesis: "Two-Step Laser Mass Spectrometry"
1986 -1990 Graduate studies in Physical and Analytical Chemistry, Stanford University. Research Advisor: Prof. Richard N. Zare
Professional and Board Memberships
2010 - present Associate Editor, Analytical Chemistry (American Chemical Society)
2009 - present Member, Israel Chemical Society
2012 - present Editorial Board, масc cпектрометрия (Moscow, Russia)
2008 - 2014 Editorial Advisory board, The Analyst (Royal Society of Chemistry)
Abstracts：
In order to perform rapid and sensitive chemical fingerprinting of exhaled breath in an on-line fashion, we explore novel ambient ionization methods in our laboratory. Ion formation at ambient pressure avoids problems with limited detection sensitivity and scope arising from introducing breath into a low-pressure environment for ionization. We are successfully using a nanoESI-based secondary electrospray ionization (SESI) for this, both in positive and negative ion modes, which affords ppb … ppt limits of detection, and detection of compounds with molecular weights up to 400 Da. Extensive statistical and chemometric evaluation of the large data set is another important element for the success of these experiments.
A number of interesting questions about metabolic signatures in the body can be addressed via on-line mass spectrometric analysis of exhaled breath: is there a core pattern for individual phenotypes visible in mass spectrometric “breathprints”? Can diurnal changes be monitored via exhaled breath? Can diseases be diagnosed via exhaled breath, and if yes, which ones? Can proper drug use (or drug abuse) be detected via analysis of the chemical composition of exhaled breath? Can Pharmacokinetics be followed ? These studies have obvious ramification for using exhaled breath as a non-invasive alternative to the analysis of blood or urine in medical diagnosis, doping control, forensics, and other areas.
Contact：Hou Keyong （9510）