Time: January 15, 2016 (Friday) 13:30pm
Location: 205 Biotechnology Building
Lecturer: Dr. Gao Chao
EDUCATION
2011-2015.03 PhD in Glycobiology, Imperial College London
Supervisor: Professor Ten Feizi
2007-2010 MSc in Pharmaceutical Chemistry, Ocean University of China (OUC)
Supervisor: Professor Huashi Guan
Cumulative Grade: 90/100; Rank: 1/40; Awarded to proceed the PhD studies directly in 2009
2003-2007 Bachelor of Pharmacy, Ocean University of China
Cumulative Grade: 87/100; Rank: 2/54
FELLOWSHIP, BURSARY AND AWARDS
Fellowship
2011-2014 PhD Fellowship from China Scholarship Council (100 awardees received full support in year 2010)
Bursary
2014 Bursary towards stipend from Henry Lester Trust Foundation
SCIENTIFIC PROJECT EXPERIENCE
Post-doc research fellow, Glycosciences Laboratory, Imperial College London
Elucidation of Carbohydrate Antigen Recognition by B-Cell Receptors of Chronic Lymphocytic Leukaemia
A dedicated carbohydrate microarray was constructed and interrogated by more than 70 B-cell receptors. These results are being assembled for publication.
PhD, Glycosciences Laboratory, Imperial College London
Characterization of Human Cancer-associated Carbohydrate Antigens
Two elusive human cancer-associated carbohydrate antigens F77 and AE3 were investigated. The prostate cancer-associated antigen F77 was fully characterized. The results have been published in JBC and presented on The 2014 Glycobiology Meeting. My data showed there are two distinct forms of the AE3 antigen which is distributed broadly among many epithelial cancers. A manuscript discussing this feature is in preparation.
MSc, Glycoscience and Glycoengineering Laboratory, OUC
Construction and Application of a Marine Oligosaccharide Library
My MSc research topic was to study the structure of alginate oligosaccharides and their sulphate derivatives as the latter have strong anti-coagulant activities comparable to heparin. It is in the biomedical and pharmaceutical aspects of carbohydrates. As a student, I performed most of the experiments and gradually built up a library of sequence-defined glycans.
PUBLICATIONS
Gao C., Zhang, Y., Liu Y., Feizi T. and Chai W. (2015). Structural Analysis by Negative-ion Electrospray Tandem Mass Spectrometry of Developmentally-regulated Antigens Based on Type 1 and Type 2 Backbone Sequences. Anal. Chem. 87, 11871-8.
Gao, C., Liu, Y., Zhang, H., Zhang, Y., Fukuda, M.N., Palma, A.S., Kozak, R.P., Childs, R.A., Nonaka, M., Li, Z., et al. (2014). Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array. J Biol Chem 289, 16462-16477.
Hirose H., Tamai H., Gao C., Imamura A., Ando H., Ishida H., Feizi T., Kiso M. (2015) Total syntheses of disulphated glycosphingolipid SB1a and the related monosulphated SM1a. Org Biomol Chem. 13, 11105-17
Nonaka, M., Fukuda, M.N., Gao, C., Li, Z., Zhang, H., Greene, M.I., Peehl, D.M., Feizi, T., and Fukuda, M. (2014). Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes. J Biol Chem 289, 16478-16486.
Catera R., Liu Y., Gao C., Yan X., Magli A., Allen S., Kolitz J., Rai K., Chu C., Feizi T., Stamatopoulos K., and Chiorazzi N. Binding of CLL subset 4 B-cell receptor immunoglobulins to human memory B lymphocytes requires a distinctive IGKV somatic mutation. Blood, submitted
Contract：Group 1803, Zhimou Guo（9541）