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Lecture: Toward Deciphering of Disease Mechanism via Mass Spectrometry-based Metabolomics

Posted: 2015-11-03

Time: November 3, 2015 (Tuesday) 9:00am

Location: Conference Room of Basic Energy Science Building

Lecturer: Prof. Xiang Zhang

RESEARCH INTEREST:

Prof. Xiang Zhang is interested in molecular systems biology, by exploiting practical and efficient high-throughput technologies for analyses of complex mixtures to facilitate the development of preventive, predictive and personalized medicine for the promotion of health and wellness. Currently, my research centers on developing high-throughput chromatography mass spectrometry-based bioanalytical platforms for proteomics and metabolomics, including two-dimensional liquid chromatography-mass spectrometry (LC×LC–MS) and comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC–MS). Using the high information content data generated from these bioanalytical platforms, we further develop advanced bioinformatics algorithms and data analysis platforms to uncover the biological information from the massive instrument data. The developed bioanalytical and bioinformatics platforms are then integrated and employed to discover molecular biomarkers and to understand the mechanisms of molecular regulation changes in a biological system.

PROFESSIONAL EXPERIENCE:

12/2013-present        Professor of Pharmacology & Toxicology, University of Louisville School of Medicine, Louisville, KY.

10/2013-present        Director, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, Louisville, KY.

07/2011-present        Professor of Chemistry, University of Louisville School of Arts & Sciences, Louisville, KY.

01/2008-06/2011        Associate Professor of Chemistry, University of Louisville School of Arts & Sciences, Louisville, KY.

04/2004-12/2007        Research Assistant Professor, Bindley Bioscience Center, Purdue University, West Lafayette, IN.

06/2001-03/2004        Senior Scientist, Beyond Genomics Medicine, Waltham, MA.

08/1996-05/2001        Research Assistant, Department of Chemistry, Purdue University, West Lafayette, IN.

08/1994-07/1996        Research Associate, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.

07/1989-07/1991        Patent Agent, Institute of Science & Technology Information of Gansu Province, Lanzhou, China.

Contract:Group 1803, Xingya Xue(9529)