Time：2015-4-10 8:50-9:20 am
Location：The Report Meeting Room, The biotech building
Lecturer: Dr. & Prof. Qingyu Zhang
Wadsworth Center, New York State Department of Health,USA
Abstract：
The mammalian intestine provides the first site for metabolism of absorbed nutrients, as well as ingested xenobiotics, including therapeutic drugs, pollutants, and chemical carcinogens. These metabolic functions are performed by a variety of biotransformation enzymes, including the cytochrome P450 enzymes. I will discuss our in vivo approach to assessing the importance of intestinal P450 enzymes in the metabolism of orally ingested drugs and other xenobiotics; the crosstalk between liver and intestine that helps to maintain overall metabolic capacity in the digestive system; and the involvement of intestinal P450 enzymes in the modulation of intestinal inflammation and immunity..
Resume of Lecturer：
Prof. Qing-Yu Zhang received a Bachelor’s degree in 1982, in Biology, from Fudan University, Shanghai, China; a MS degree in 1984, in Biochemistry, from Tulane University, New Orleans, Louisiana; and a PhD degree in 1989, in Biological Chemistry, from the University of Michigan, Ann Arbor, Michigan, USA. She is currentlya Senior Research Scientist in Wadsworth Center, New York State of Department of Health, and Associate Professor in School of Public Health, State University of New York at Albany, NY, USA. Prof Zhang studies the function and regulation of intestinal P450 enzymes. The overall goal of her group has been to study the roles of intestinal P450 enzymes in drug metabolism, toxicity, and etiology of major diseases that affect the digestive system, and to learn how intestinal P450 expression and function are altered by physiological, pathological or environmental factors.
Contact：1806 group Guang-Bo Ge (Dr. & Asso. Prof.) （Tel: 84379317-601）