Upcoming Events

Lecture:Role of Microsomal P450 Enzymes in Drug Response, Carcinogenesis, and Disease Susceptibility

Posted: 2015-04-10
 

Time:2015-4-10 8:20-8:50 am

Location:The Report Meeting Room, The biotech building

Lecturer: Dr. & Prof. Xinxin Ding

College of Nanoscale Science, SUNY Polytechnic Institute,USA

Abstract:

Microsomal cytochrome P450 monooxygenases have diverse functions in various organ systems, through their metabolism of numerous drugs, chemical carcinogens, environmental pollutants, as well as endogenous signaling molecules. I will describe our efforts to develop novel transgenic and knockout mouse models for determination of the roles of P450 enzymes in modulating the bioavailability and/or tissue-selective toxicity of drugs and other xenobiotic compounds, and for exploration of their potential biological functions and disease connections.

Resume of Lecturer:

Prof. Xinxin Ding received a Bachelor’s degree in 1982, in Biology, from Nanjing University, and a Ph.D degree in 1988, in Biological Chemistry, from the University of Michigan, Ann Arbor, Michigan, USA. He is currently Professor of Nanobioscience, Director of Laboratory of Molecular Toxicology, and Director of Center for Preclinical Nano-Drug Discovery and Development at State University of New York Polytechnic Institute, College of Nanoscale Science and Engineering, Albany, NY, USA. Prof. Ding studies the function and regulation of microsomal cytochrome P450 enzymes in various organ systems. A major area of his research involves development and application of genetically engineered mouse models for drug metabolism and toxicology studies. Prof. Ding is currently an Associate Editor for Drug Metabolism and Disposition and Acta Pharmaceutica Sinica (B). He was a recipient of the Distinguished Chinese Toxicologist Lectureship Award by the American Association of Chinese in Toxicology, the Society of Toxicology.

Contact:1806 group Guang-Bo Ge (Dr. & Asso. Prof.) (Tel: 84379317-601)