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Time: Auguest 27, 2014 9:10 AM
Location:Conference Hall of Biology Building
Reporter:Prof. Frank J. Gonzalez
National Cancer Institute, USA
Biography:
Professor Frank J. Gonzales is the chief of laboratory of metabolism, Center for Cancer Research, National Cancer Institute, USA. His lab carried out many cloning and expression of rodents and human CYP genes. His lab also developed many of P450s enzymes, gene transcription factors and nuclear receptors mice knockout models. These models can be used to study the role of knockout genes in mammalian development, physiological state, toxicity and carcinogenic aspects. His group also constructed many humanized mice models which express human CYP450 enzymes and some xenobiotic receptors. Among them, the construction of humanized peroxisome proliferation activated receptors (PPAR) mice model is a breakthrough in the study of non-genetic carcinogenesis causing by some chemical carcinogen and chemical risk assessmentin human. Prof. Gonzales's team gained great achievement in metabolomics research field as well. His group cooperated with many research teams within NCI and NIH as well as some international laboratories, to search the bio-markers for disease diagnosis, prognosis and treatment etc., such as type II diabetes and cancer. This technology can be used to study drug and carcinogen metabolism, predict drug efficacy and toxicity and disease pathogenesis. Prof. Gonzalez currently serves as editorial board of Molecular Pharmacology, Journal of Biological Chemistry, Gastroenterology, Molecular Endocrinology, Carcinogenesis, etc. He is one of the founder and editor of Pharmacogenetics. Prof. Gonzalez’s group has published more than 960 papers, including the top academic journals such as Cell, Nature, Science, Nature Medicine, Cell Metabolism, Journal of Clinical Investigation, Gastroenterology, Hepatology etc.
Abstract:
Metabolomics is an important component of systems biology, which is an omics technology developed following genomics, transcriptomics and proteomics. Metabolomics, by quantification analysis all the metabolites in vivo, study the relationship between metabolites and physiological pathological changes. Prof. Gonzalez will start from the application of metabolomics in drug metabolism, drug toxicity mechanism analysis, disease pathogenesis and target identification aspects to explain the important role of metabolomics in biomedical field. In addition, Professor Gonzalez will also display the cross application of gene knockout mice models with metabolomics，which greatly amplify the advantages of metabolomics.
Contacts:Prof. Guangbo Ge (Group1806, 84379317) |