The kick-off meeting for the National Program on Key Research and Development Project “Development of New Methods for Comprehensive Analysis of Protein Complexes with dynamic changes” was held in DICP on October 28th-29th. The meeting was chaired by Yukui Zhang (Member of Chinese Academy of Science, Dalian Institute of Chemical Physics). There were ten experts, including Erkang Wang (Member of Chinese Academy of Science, Changchun Institute of Applied Chemistry academician), Qiankun Zhuang (The National Natural Science Foundation of Department of Chemistry), and more than 50 project participants attended the conference. The chief scientist, professor Mingliang Ye, firstly introduced the project and other professors also introduced the sub-project and their plans. The experts discussed the project and put forward many constructive suggestions.
Proteins are the fundamentals in biological life, and protein-protein interactions (PPIs) play important roles during many biological functions. Thus, comprehensive analysis of protein complexes could help us to understand the PPIs. The project “Development of New Methods for Comprehensive Analysis of Protein Complexes with dynamic changes” is mainly focused on the characterizations of protein complexes at largescale, which could be in favor with the PPI analysis. The project will be performed on two dimensions: one dimension is development of new methods for identification of protein complexes and PTM dependent interaction sites, which analyze functional protein complexes with space-time dynamic changes; another dimension is the analysis of protein complexes during whole cell signal-transduction pathway by using the developed methods, which includes the processes from cell membranes to cell nuclear. Thus above, comprehensive analysis of protein complexes could be completed by using the newly developed methods, which has great potential applications in the study of mechanisms of tumor progress and drug-resistance.
