Prof. ZHUANG Zheng-ping (head of Molecular Pathogenesis Unit) from Surgical Neurology Branch, NIH/NIC visited Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences (CAS) .On Jun. 27, in the conference hall of division of biotechnology, he gave an excellent lecture about Hypoxia Signaling and Tumorigenesis: Implications for Tumor Therapy. Scientists from biotechnology department and the relevant research groups attended the lecture.
Prof. ZHUANG Zhengping Visites Dalian Institute of Chemical Physics (Photo by LIU Xiumei)
Prof. ZHUANG firstly summarized the important function of HIFs in tumorigenesis. Based on his own study, he introduced the pathological roles of EPO/EPOR activation in JAK/STAT signaling transduction pathway under Hypoxia condition. Next, Prof. Zhuang shared the strategy of how to inhibit hypoxia signaling by small compound inhibitors in tumorigenesis. Finally, Prof. Zhuang presented the negative effect of clinical tried drugs in glioblastoma. After seminar, Prof. Zhuang discussed recent hot topics on translational research with attenders.
Prof. ZHUANG received his Ph.D. from Wayne State University, and joined the Surgical Neurology Branch, NINDS, NIH as a head of Molecular Pathogenesis Unit since 1999. Dr. Zhuang is actively involved in both clinical and research work. He has more than 300 publications in prestigious journals including New England Journal of Medicine, Lancet, Science, PNAS, Nature Genetics, Journal of Clinical Oncology and he co-discovered three important disease genes for Multiple Endocrine Neoplasia Type 1 (Menin), Papillary Renal Carcinoma (c-MET) and a novel syndrome with Multiple Paraganlioma, Somatostatinoma and Polycythemia (HIF2A). He pioneered the tissue microdissection technique and is a co-inventor of the laser capture microdissection microcopy (LCM) (Text by LIU Xiumei, PIAO Hailong/ Photo by LIU Xiumei) .