New progress has been attained in the study of a qualitative analysis method for markers in metabonomics by the DICP research team of Prof. XU Guowang in collaboration with Dr. Rainer Lehmann of the Tübingen University. Their research results were published in the journal of Analytical Chemistry(http://dx.doi.org/10.1021/ac702089h), and was recommended in the "Laboratory Informatics Ezine" column by the "separationNOW.com" web of John Wiley & Sons, Ltd., with the title of "To identify me is to know me".
The search of biological markers with new specificity is a hot and difficult topic in current disease researches. The scheme proposed by Prof. XU and Dr. Lehmann(Fig. 1) succeeded for the first time in qualitative identifying metabolic markers through the correlating of the segmenting behavior of mass spectrometry with the retention behavior of chromatography. They utilized the marker(m/z = 194) obtained from the investigation of insulin-resisting metabonomics as an example to illustrate the feasibility of their scheme.