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  English.dicp.cas.cn    Posted:2017-05-31
Lecture: Optical Imaging of Nanoscale Chemical and Biological Processes

Time: 2017.05.31 14:00-15:00
Location: Room 204, Energy Conference Center
Lecturer: Ning Fang Associate Professor
Department of Chemistry, Georgia State University

The research in the Fang Laboratory aims to open up new frontiers in chemical and biological discovery through the development and use of novel optical imaging platforms, which provide sub-diffraction-limited spatial resolution, high angular resolution, excellent detectability, and/or nanometer localization precision for single molecules and nanoparticles.
?Rotational Tracking: The knowledge of rotational dynamics in and on live cells remains highly limited due to technical limitations. The differential interference contrast (DIC) microscopy-based Single Particle Orientation and Rotational Tracking (SPORT) techniques have been developed in the Fang Laboratory to acquire accurate measurements of anisotropic plasmonic gold nanorods in complex cellular environments. Rich information in five dimensions, including the x, y, z coordinates and the two orientation angles (azimuthal angle ? and polar angle ? , as defined in the figure) of the probe’s transition dipole, can be obtained from SPORT experiments. The SPORT technique is capable of extracting important information (including rotational rates, modes, and directions) on the characteristic rotational dynamics involved in cellular processes, such as adhesion, endocytosis, and transport of functionalized nanoparticles, as may be relevant to drug delivery and viral entry.
?Single Molecule Catalysis: The emergence of single molecule-based super-localization and super-resolution microscopy imaging techniques have dramatically improved our ability to reveal more detailed molecular dynamics and structural information and led to new discoveries in chemical and biological research that were previously unattainable with conventional diffraction-limited techniques. However, the current super-resolution chemical imaging techniques still lack several critical abilities, including insufficient axial resolution and the difficulty of imaging more complex three-dimensional (3D) nanomaterials. In seeking to circumvent these limitations, we are developing 3D super-resolution imaging for understanding molecular dynamics (including diffusion, adsorption, and chemical conversion, as well as their coupling) in nanopores at the single-molecule level under operando conditions. Highly tunable core-shell structures with well-defined geometry and manageable complexity have been designed and synthesized, and then visualized under our optical imaging system. Single molecule trajectories with nanometer resolution have been acquired to elucidate the effects of pore size, length, orientation, and surface ligands on molecular transport. New experimental insights on transport in nanoscale confinement acquired with the model core-shell porous structures can be generalized to guide the development of porous materials for heterogeneous catalysis and analytical separations.


Ning Fang Associate Professor Department of Chemistry, Georgia State University
07/2015 – Present
Associate Professor, Department of Chemistry, Georgia State University
08/2008 – 05/2015
Assistant Professor, Department of Chemistry, Iowa State University
Faculty Scientist, Ames Laboratory, U.S. Department of Energy
/2015 Innovation Award by the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS).
/Awarded to the Five-Dimensional Single Particle Tracking technique
/The 2008 Best Paper of the Year Award, Journal of Analytical and Bioanalytical Chemistry.
/Chinese Government Award for Outstanding Self-Financed Students Abroad, 2006.
Contact: BAI Xue (84379390) 



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