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  English.dicp.cas.cn    Posted:2010-09-06
Mass Spectrometry for Unraveling the Molecular Mechanisms of Action of Anti-cancer Drugs

  Time:Aug. 4 2010 AM10:00

  Location:Academic Hall of Biological Building

  Yinsheng Wang

  Department of Chemistry,University of California at Riverside,USA


  Yinsheng Wang received his B. S. and M. S. degrees from Shandong University in 1993 and Dalian Institute of Chemical Physics in 1996, respectively.  After obtaining his Ph. D. degree from Washington University in St. Louis in 2001, he joined the faculty of the Chemistry Department of the University of California Riverside, where he is now a Professor of Chemistry and the Director for the Environmental Toxicology Graduate Program.  The research in his group has been concentrated on understanding the chemistry and biological implications of DNA damage induced by various endogenous and exogenous agents. More recently, his laboratory has also been working with the post-translational modifications of proteins and using quantitative proteomics tools for assessing the mechanisms of action of anti-tumor drugs and environmental pollutants.


  With the recent advances in mass spectrometry instrumentation, particularly the development of instruments capable of high-resolution and high-mass accuracy measurements, now thousands of proteins from the entire proteome can be quantified.  We reason that a systematic investigation about the changes in global protein expression in human cells that are exposed to anti-cancer drugs will offer novel insights into the cellular pathways that are perturbed by these drugs, thereby providing new knowledge for understanding the mechanisms in developing drug resistance and for developing new and more effective anti-cancer therapy.  In this presentation, I will discuss our recent effort in combining stable isotope labeling by amino acid in cell culture (SILAC) with mass spectrometry for unraveling the new pathways that are perturbed by several anti-leukemia agents including arsenite, doxorubicin and 6-thioguanine.  We will show that these drugs may act through cellular pathways that have not been previously recognized.




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