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Minireview on Inert C=N Bond Activation
  English.dicp.cas.cn    Posted:2012-06-21

A minireview entitled “BrΦnsted Acid Activation Strategy in Transition Metal-Catalyzed Asymmetric Hydrogenation of Unprotected N-H Imines, Enamines and N-Heteroaromatics” was recently published in Angew. Chem. Int. Ed. by Prof. Dr. Zhengkun Yu from the Laboratories of Organometallic Catalysis and Synthesis (Lab 203) (Angew. Chem. Int. Ed. 2012, 51(25), 6060-6072.http://onlinelibrary.wiley.com/doi/10.1002/anie.201200963/pdf).

Asymmetric hydrogenation plays an important role in organic synthesis, but that of the challenging substrates, i.e., unprotected N-H imines, enamines and N-heteroaromatics with poor aromaticity (1H-indoles, 1H-pyrroles, pyridines, quinolines and quinoxalines) has only received growing attention in the past three years. Considering the interaction modes of a BrΦnsted acid with a Lewis base, BrΦnsted acids may be used as the ideal activators of C=N bonds.This minireview summarizes the recent advances in transition metal-catalyzed, BrΦnsted acid-activated asymmetric hydrogenation of these challenging substrates, offering a promising substrate activation strategy in the transformations involving C=N bonds. This paper is the first review on the relevant topic in asymmetric hydrogenation.

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