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  English.dicp.cas.cn    Posted:2013-10-23
SKLMRD-TC Joint Talk Series (No.44)- Biomimetic Metal-Oxygen Intermediates in Dioxygen Activation Chemistry

Time: 2013.10.25 (Friday) 13:30 pm 

Location: SKLMRD Meeting Room (36 Building, third floor)

Lecturer: Prof. Wonwoo Nam 

Ewha Womans University, Korea   

Abstract: 

Dioxygen is essential in life processes, and enzymes activate dioxygen to carry out a variety of biological reactions. One primary goal in biomimetic research is to elucidate structures of reactive intermediates and mechanistic details of dioxygen activation and oxygenation reactions occurring at the active sites of enzymes, by utilizing synthetic metal-oxygen complexes. A growing class of metal-oxygen complexes, such as metal–superoxo, –peroxo, –hydroperoxo, and –oxo species, have been isolated, characterized spectroscopically, and investigated in various oxygenation reactions. During the past decade, we have been studying the chemical and physical properties of various reactive intermediates in oxygenation reactions, such as high-valent iron(IV)- and manganes(V)-oxo complexes of heme and non-heme ligands in oxo-transfer and C-H activation reactions, non-heme metal-peroxo complexes in nucleophilic reactions, and non-heme metal-superoxo complexes in electrophilic reactions. The effects of supporting and axial ligands on structural and spectroscopic properties and reactivities of metal-oxygen adducts have been extensively investigated as well. In this presentation, I will present our recent results on the reactivities of various metal-oxygen intermediates in electrophilic and nucleophilic oxidation reactions. The synthesis and structural and spectroscopic characterization of mononuclear nonheme metal-dioxygen intermediates will be discussed as well.   

Keywords: Bioinorganic Chemistry; Biomimetic Compound; Dioxygen Activation; Metal-Oxygen Intermediates    

Reference: 

[1] Cho, J.; Sarangi, R.; Nam, W. Acc. Chem. Res. 2012, 45, 1321. 

[2] Cho, J.; Jeon, S.; Wilson, S. A.; Liu, L. V.; Kang, E. A.; Braymer, J. J.; Lim, M. H.; Hedman, B.; Hodgson, K. O.; Valentine, J. S.; Solomon, E. I.; Nam, W. Nature 2011, 478, 502. 

[3] Fukuzumi, S.; Kishi, T.; Kotani, H.; Lee, Y.-M.; Nam, W. Nature Chem. 2011, 3, 38. 

[4] Fukuzumi, S.; Morimoto, Y.; Kotani, H.; Naumov, P.; Lee, Y.-M.; Nam, W. Nature Chem. 2010, 2, 756.  

[5] Cho, J.; Sarangi, R.; Annaraj, J.; Kim, S. Y.; Kubo, M.; Ogura, T.; Solomon, E. I.; Nam, W. Nature Chem. 2009, 1, 568. 

[6] Nam, W. Acc. Chem. Res. 2007, 40, 465; Guest editorial in a special issue on “Dioxygen Activation by Metalloenzymes and Models”.  

[7] Nam, W. Acc. Chem. Res. 2007, 40, 522. 

[8] Bukowski, M. R.; Koehntop, K. D.; Stubna, A.; Bominaar, E. L.; Halfen, J. A.; Münck, E.; Nam, W.; Que, L., Jr. Science 2005, 310, 1000. 

[9] Rohde, J.–U.; In, J.–H.; Lim, M. H.; Brennessel, W. W.; Bukowski, M. R.; Stubna, A.; Münck, E.; Nam, W.; Que, L., Jr. Science 2003, 299, 1037. 

Introduction: 

 Prof. Nam graduated from California State University, Los Angeles and got his B.S. degree in 1985, and received his Ph.D. in 1990 (Advisor: Professor Joan S. Valentine at UCLA). After two year’s postdoc research at UCLA, he moved to Hong Ik University as an assistant professor. Then, he entered Ewha Womans University as an associate professor (in 1994), and a full professor (in 2000). He is the director of center for biomimetic systems, chair of director of Korean Academy of Science and Technology. He is also honorary professor of University of Hong Kong, and concurrent professor of Nanjing University. He has published more than 300 papers at Science, Nature, etc. journals, and is the associate editor of Chemical Science Journal.  

Contact: Group 1101, Yong Wang (9763) 

 
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